High affinity CB1 receptor antagonist (Ki = 4.1 nM). Exhibits significantly reduced lipophilicity compared to other CB1 antagonists.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 459.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.18 mL||10.88 mL||21.77 mL|
|5 mM||0.44 mL||2.18 mL||4.35 mL|
|10 mM||0.22 mL||1.09 mL||2.18 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Katoch-Rouse et al (2003) Synthesis, structure-activity relationship and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity. J.Med.Chem. 46 642 PMID: 12570386
Miller et al (2007) Analogs of SR-141716A (Rimonabant) alter d-amphetamine-evoked [3H] dopamine overflow from preloaded striatal slices and amphetamine-induced hyperactivity. Life Sci. 81 63 PMID: 17532007
If you know of a relevant reference for NIDA 41020, please let us know.
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Keywords: NIDA41020 cannabinoid receptors antagonists CB1 selective CB1 Receptors
1 Citation for NIDA 41020
Citations are publications that use Tocris products. Selected citations for NIDA 41020 include:
Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129
Do you know of a great paper that uses NIDA 41020 from Tocris? If so please let us know.
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