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Discontinued ProductNIDA 41020 (Cat. No. 3921) has been withdrawn from sale for commercial reasons.
High affinity CB1 receptor antagonist (Ki = 4.1 nM). Exhibits significantly reduced lipophilicity compared to other CB1 antagonists.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Katoch-Rouse et al (2003) Synthesis, structure-activity relationship and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity. J.Med.Chem. 46 642 PMID: 12570386
Miller et al (2007) Analogs of SR-141716A (Rimonabant) alter d-amphetamine-evoked [3H] DA overflow from preloaded striatal slices and amphetamine-induced hyperactivity. Life Sci. 81 63 PMID: 17532007
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Keywords: NIDA 41020, NIDA 41020 supplier, NIDA41020, cannabinoid, receptors, antagonists, CB1, selective, Receptors, 3921, Tocris Bioscience
1 Citation for NIDA 41020
Citations are publications that use Tocris products. Selected citations for NIDA 41020 include:
Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.