You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for NI 57
NI 57 is a potent and selective BRPF bromodomain inhibitor (Kd values are 31, 108 and 408 nM, for BRPF1B, 2 and 3, respectively, which exhibits >32-fold selectivity for BRPFs over BRD9 and other non-Class IV bromodomains. NI 57 inhibits RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into osteoclasts.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NI 57 probe summary on the SGC website.
External Portal Information for NI 57
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of NI 57 is reviewed on the chemical probes website.
Compound Libraries for NI 57
Technical Data for NI 57
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NI 57
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NI 57
The following data is based on the product molecular weight 383.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.61 mL||13.04 mL||26.08 mL|
|5 mM||0.52 mL||2.61 mL||5.22 mL|
|10 mM||0.26 mL||1.3 mL||2.61 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
References for NI 57
References are publications that support the biological activity of the product.
Igoe et al (2017) Design of a chemical probe for the bromodomain and plant homeodomain finger-containing (BRPF) family of proteins. J.Med.Chem. 60 6998 PMID: 28714688
Meier et al (2017) Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation. ACS Chem.Biol. 12 2619 PMID: 28849908
If you know of a relevant reference for NI 57, please let us know.
View Related Products by Product Action
Keywords: NI 57, NI 57 supplier, NI57, potent, and, selective, bromodomain, inhibitors, inhibits, BRPF, sgc, structural, genomics, consortium, Bromodomains, 5546, Tocris Bioscience
Citations for NI 57
Citations are publications that use Tocris products.
Currently there are no citations for NI 57. Do you know of a great paper that uses NI 57 from Tocris? Please let us know.
Reviews for NI 57
There are currently no reviews for this product. Be the first to review NI 57 and earn rewards!
Have you used NI 57?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.