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Selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.
R-enantiomer also available.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||1.97||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 393.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||25.42 mL||127.08 mL||254.16 mL|
|0.5 mM||5.08 mL||25.42 mL||50.83 mL|
|1 mM||2.54 mL||12.71 mL||25.42 mL|
|5 mM||0.51 mL||2.54 mL||5.08 mL|
References are publications that support the biological activity of the product.
Bergeron et al (1998) Modulation of N-MthD.-aspartate receptor function by glycine transport. Proc.Natl.Acad.Sci.USA 95 15730
Harsing Jr. et al (2003) The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study. Pharmacol.Biochem.Behav. 74 881
Mallorga et al (2003) Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology 45 585 PMID: 12941372
If you know of a relevant reference for NFPS, please let us know.
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Keywords: NFPS, NFPS supplier, Selective, non-transportable, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, (+/-)-NFPS, 2789, Tocris Bioscience
2 Citations for NFPS
Citations are publications that use Tocris products. Selected citations for NFPS include:
Romei et al (2016) Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission. Brain Research Bulletin 127 100 PMID: 27565422
DeBrouse et al (2013) Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site. Alcohol Clin Exp Res 37 223 PMID: 22934986
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Literature in this Area
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.