ALX 5407 hydrochloride

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Description: Selective non-transportable GlyT1 inhibitor
Alternative Names: (+)-NFPS
Chemical Name: N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for ALX 5407 hydrochloride

ALX 5407 hydrochloride is a selective non-transportable inhibitor of the glycine transporter GlyT1 (IC50 values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC50 > 100 μM).

Racemate also available.

Licensing Information

Sold with the permission of NPS Pharmaceuticals Inc. Strictly for in vitro use only

Compound Libraries for ALX 5407 hydrochloride

ALX 5407 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ALX 5407 hydrochloride

M. Wt 429.92
Formula C24H24FNO3.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 200006-08-2
PubChem ID 16078946
Smiles FC(C=C2)=CC=C2[C@@H](CCN(CC(O)=O)C)OC1=CC=C(C3=CC=CC=C3)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ALX 5407 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 21.5 50
DMSO 42.99 100

Preparing Stock Solutions for ALX 5407 hydrochloride

The following data is based on the product molecular weight 429.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.63 mL 23.26 mL
5 mM 0.47 mL 2.33 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets for ALX 5407 hydrochloride

Certificate of Analysis / Product Datasheet
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References for ALX 5407 hydrochloride

References are publications that support the biological activity of the product.

Atkinson et al (2001) ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol.Pharmacol. 60 1414 PMID: 11723250

Lipina et al (2005) Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to cloz. in mouse models of schizophrenia. Psychopharmacology 179 54 PMID: 15759151

If you know of a relevant reference for ALX 5407 hydrochloride, please let us know.

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1 Citation for ALX 5407 hydrochloride

Citations are publications that use Tocris products. Selected citations for ALX 5407 hydrochloride include:

Yue et al (2016) Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity. Nat.Commun. 7 13501 PMID: 27874011

Do you know of a great paper that uses ALX 5407 hydrochloride from Tocris? Please let us know.

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