NF 340

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Cat.No. 3830 - NF 340 | C37H26N4Na4O15S4 | CAS No. 202982-98-7
Description: Selective P2Y11 antagonist
Chemical Name: 4,4'-(Carbonylbis(imino-3,1-(4-methyl-phenylene)carbonylimino))bis(naphthalene-2,6-disulfonic acid) tetrasodium salt
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

P2Y11 antagonist; exhibits 520-fold selectivity for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6 and P2Y12 receptors. Displays competitive antagonism against ATPγS (pIC50 values are 6.43 and 7.14 in Ca2+ and cAMP assays respectively).

Technical Data

M. Wt 986.84
Formula C37H26N4Na4O15S4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 202982-98-7
PubChem ID 73755007
InChI Key SJMHXBFWMZYDBY-UHFFFAOYSA-J
Smiles [Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)NC1=C(C)C=CC(=C1)C(=O)NC1=CC(=CC2=C1C=C(C=C2)S([O-])(=O)=O)S([O-])(=O)=O)C(=O)NC1=CC(=CC2=C1C=C(C=C2)S([O-])(=O)=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.74 20

Preparing Stock Solutions

The following data is based on the product molecular weight 986.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.01 mL 5.07 mL 10.13 mL
5 mM 0.2 mL 1.01 mL 2.03 mL
10 mM 0.1 mL 0.51 mL 1.01 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Meis et al (2010) NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk J.Pharmacol.Exp.Ther. 332 238 PMID: 19815812


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Keywords: NF 340, supplier, P2Y11, purinoceptors, purines, receptors, antagonists, NF340, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience

2 Citations for NF 340

Citations are publications that use Tocris products. Selected citations for NF 340 include:

Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29 PMID: 24886406

Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Autophagy 9 31 PMID: 22825617


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