NF 340

Discontinued Product

NF 340 (Cat. No. 3830) has been withdrawn from sale for commercial reasons.
Description: Selective P2Y11 antagonist
Chemical Name: 4,4'-(Carbonylbis(imino-3,1-(4-methyl-phenylene)carbonylimino))bis(naphthalene-2,6-disulfonic acid) tetrasodium salt
Purity: ≥95% (HPLC)
Citations (7)
Literature (1)

Biological Activity for NF 340

P2Y11 antagonist; exhibits 520-fold selectivity for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6 and P2Y12 receptors. Displays competitive antagonism against ATPγS (pIC50 values are 6.43 and 7.14 in Ca2+ and cAMP assays respectively).

Technical Data for NF 340

M. Wt 986.84
Formula C37H26N4Na4O15S4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 202982-98-7
PubChem ID 73755007
Smiles [Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)NC1=C(C)C=CC(=C1)C(=O)NC1=CC(=CC2=C1C=C(C=C2)S([O-])(=O)=O)S([O-])(=O)=O)C(=O)NC1=CC(=CC2=C1C=C(C=C2)S([O-])(=O)=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for NF 340

Certificate of Analysis / Product Datasheet
Select another batch:

References for NF 340

References are publications that support the biological activity of the product.

Meis et al (2010) NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk J.Pharmacol.Exp.Ther. 332 238 PMID: 19815812

View Related Products by Target

View Related Products by Product Action

View all Purinergic (P2Y) Receptor Antagonists

Keywords: NF 340, NF 340 supplier, P2Y11, purinoceptors, purines, receptors, antagonists, NF340, Purinergic, P2Y, Receptors, 3830, Tocris Bioscience

7 Citations for NF 340

Citations are publications that use Tocris products. Selected citations for NF 340 include:

Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Autophagy 9 31 PMID: 22825617

Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29 PMID: 24886406

Dreisig et al (2018) Human P2Y11 Expression Level Affects Human P2X7 Receptor-Mediated Cell Death. Front Immunol 9 1159 PMID: 29937766

Kinoshita et al (2018) Anti-Depressant Flu Reveals its Therapeutic Effect Via Astrocytes. EBioMedicine 32 72 PMID: 29887330

Reviews for NF 340

There are currently no reviews for this product. Be the first to review NF 340 and earn rewards!

Have you used NF 340?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.