NF 279

Pricing Availability Delivery Time Qty
Cat.No. 1199 - NF 279 | C49H30N6Na6O23S6 | CAS No. 202983-32-2
Description: Potent and selective P2X1 antagonist
Chemical Name: 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Datasheet
Citations (8)
Literature

Biological Activity

A potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 μM), P2X3 (IC50 = 1.62μM), P2X4 (IC50 > 300 μM), P2Y receptors and ecto-nucleotidases.

Technical Data

M. Wt 1401.1
Formula C49H30N6Na6O23S6
Storage Desiccate at -20°C
CAS Number 202983-32-2
PubChem ID 4467
InChI Key RJMCMLNRWDKUDB-UHFFFAOYSA-H
Smiles [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC2=C(C(NC(=O)C3=CC=C(NC(=O)C4=CC=C(NC(=O)NC5=CC=C(C=C5)C(=O)NC5=CC=C(C=C5)C(=O)NC5=C6C(C=C(C=C6S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C5)S([O-])(=O)=O)C=C4)C=C3)=CC=C2S([O-])(=O)=O)C(=C1)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.01 10
water 35.03 25

Preparing Stock Solutions

The following data is based on the product molecular weight 1401.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.71 mL 3.57 mL 7.14 mL
5 mM 0.14 mL 0.71 mL 1.43 mL
10 mM 0.07 mL 0.36 mL 0.71 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Damer et al (1998) NF279: a novel potent and selective antagonist of P2X receptor-mediated responses. Eur.J.Pharmacol. 350 R5 PMID: 9683026

Klapperstuck et al (2000) Antagonism by the suramin analogue NF 279 on human P2X1 and P2X7 receptors. Eur.J.Pharmacol. 387 245 PMID: 10650169

Rettinger et al (2000) The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor. Neuropharmacology 39 2044 PMID: 10963748


If you know of a relevant reference for NF 279, please let us know.

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Keywords: NF 279, supplier, Potent, selective, P2X1, antagonists, Receptors, Purinergic, purinoceptors, NF279, P2X, Receptors, Tocris Bioscience

8 Citations for NF 279

Citations are publications that use Tocris products. Selected citations for NF 279 include:

Donnelly-Roberts et al (2009) Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol 157 1203 PMID: 19558545

Luke and Hexum (2008) UTP and ATP increase extracellular signal-regulated kinase 1/2 phosphorylation in bovine chromaffin cells through epidermal growth factor receptor transactivation. Mediators Inflamm 4 323 PMID: 18777108

Kennedy et al (2007) Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. J Neurosci 27 845 PMID: 17251425

Inscho et al (2003) Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. J Clin Invest 112 1895 PMID: 14679185

Aliagas et al (2014) High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors. PLoS One 2014 509027 PMID: 24707115

Aliagas et al (2013) Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis". Purinergic Signal 9 599 PMID: 23771238

Ibáñez et al (2012) A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen 15 359 PMID: 22256970

Hazleton et al (2012) Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol 188 4488 PMID: 22450808


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