NF 279

Pricing Availability   Qty
Description: Potent and selective P2X1 antagonist
Chemical Name: 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Purity: ≥95% (HPLC)
Citations (9)
Literature (5)

Biological Activity for NF 279

NF 279 is a a potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 μM), P2X3 (IC50 = 1.62μM), P2X4 (IC50 > 300 μM), P2Y receptors and ecto-nucleotidases.

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Technical Data for NF 279

M. Wt 1401.1
Formula C49H30N6Na6O23S6
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 202983-32-2
PubChem ID 4467
Smiles [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC2=C(C(NC(=O)C3=CC=C(NC(=O)C4=CC=C(NC(=O)NC5=CC=C(C=C5)C(=O)NC5=CC=C(C=C5)C(=O)NC5=C6C(C=C(C=C6S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C5)S([O-])(=O)=O)C=C4)C=C3)=CC=C2S([O-])(=O)=O)C(=C1)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NF 279

Solvent Max Conc. mg/mL Max Conc. mM
water 25 18

Preparing Stock Solutions for NF 279

The following data is based on the product molecular weight 1401.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.18 mM 3.97 mL 19.83 mL 39.65 mL
0.9 mM 0.79 mL 3.97 mL 7.93 mL
1.8 mM 0.4 mL 1.98 mL 3.97 mL
9 mM 0.08 mL 0.4 mL 0.79 mL

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Product Datasheets for NF 279

Certificate of Analysis / Product Datasheet
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References for NF 279

References are publications that support the biological activity of the product.

Damer et al (1998) NF279: a novel potent and selective antagonist of P2X receptor-mediated responses. Eur.J.Pharmacol. 350 R5 PMID: 9683026

Klapperstuck et al (2000) Antagonism by the suramin analogue NF 279 on human P2X1 and P2X7 receptors. Eur.J.Pharmacol. 387 245 PMID: 10650169

Rettinger et al (2000) The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor. Neuropharmacology 39 2044 PMID: 10963748

If you know of a relevant reference for NF 279, please let us know.

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Keywords: NF 279, NF 279 supplier, Potent, selective, P2X1, antagonists, Receptors, Purinergic, purinoceptors, NF279, P2X, 1199, Tocris Bioscience

9 Citations for NF 279

Citations are publications that use Tocris products. Selected citations for NF 279 include:

Ibáñez et al (2012) A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen 15 359 PMID: 22256970

Hazleton et al (2012) Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol 188 4488 PMID: 22450808

Donnelly-Roberts et al (2009) Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol 157 1203 PMID: 19558545

Inscho et al (2003) Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. J Clin Invest 112 1895 PMID: 14679185

Do you know of a great paper that uses NF 279 from Tocris? Please let us know.

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Literature in this Area

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