NF 110

Pricing Availability   Qty
Description: Potent P2X3 antagonist
Chemical Name: 4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonic acid tetrasodium salt
Purity: ≥90% (HPLC)
Citations (4)
Literature (1)

Biological Activity for NF 110

NF 110 is a high affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively). Shows no activity at P2Y1, P2Y2 and P2Y11 receptors (IC50 > 10 μM). Potently inhibits α,β-meATP-evoked desensitizing currents in rat DRG neurons (IC50 = 527 nM). Shows antitumor activity against several tumor types. Also inhibits DNA-binding activity of HMGA2 (IC50 = 0.87 μM).

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Technical Data for NF 110

M. Wt 1096.9
Formula C41H28N6Na4O17S4
Storage Desiccate at RT
Purity ≥90% (HPLC)
CAS Number 111150-22-2
PubChem ID 16066783
Smiles [Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC=C(NC(=O)C2=CC(=CC(NC(=O)NC3=CC(=CC(=C3)C(=O)NC3=CC=C(C=C3)S([O-])(=O)=O)C(=O)NC3=CC=C(C=C3)S([O-])(=O)=O)=C2)C(=O)NC2=CC=C(C=C2)S([O-])(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NF 110

Solvent Max Conc. mg/mL Max Conc. mM
water 40 37

Preparing Stock Solutions for NF 110

The following data is based on the product molecular weight 1096.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.37 mM 2.46 mL 12.32 mL 24.64 mL
1.85 mM 0.49 mL 2.46 mL 4.93 mL
3.7 mM 0.25 mL 1.23 mL 2.46 mL
18.5 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets for NF 110

Certificate of Analysis / Product Datasheet
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Keywords: NF 110, NF 110 supplier, Potent, P2X3, antagonists, Receptors, Purinergic, purinoceptors, NF110, HMGA2, inhibitors, inhibits, high, mobility, group, protein, AT-hook, 2, DNA, binding, P2X, 2548, Tocris Bioscience

4 Citations for NF 110

Citations are publications that use Tocris products. Selected citations for NF 110 include:

Dosch et al (2019) Connexin-43-dependent ATP release mediates macrophage activation during sepsis. Elife 8 PMID: 30735126

Chandra et al (2019) Decoy Receptor Interactions as Novel Drug Targets against EKC-Causing Human Adenovirus. Viruses 11 PMID: 30870979

Nishimura et al (2015) The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog 11 e1005184 PMID: 26430888

Su et al (2020) Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci Rep 10 18850 PMID: 33139812

Do you know of a great paper that uses NF 110 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.