NF 110

Pricing Availability   Qty
Cat.No. 2548 - NF 110 | C41H28N6Na4O17S4 | CAS No. 111150-22-2
Description: Potent P2X3 antagonist
Chemical Name: 4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonic acid tetrasodium salt
Datasheet
Citations (3)
Reviews
Literature (5)

Biological Activity

High affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively). Shows no activity at P2Y1, P2Y2 and P2Y11 receptors (IC50 > 10 μM). Potently inhibits α,β-meATP-evoked desensitizing currents in rat DRG neurons (IC50 = 527 nM). Shows antitumor activity against several tumor types.

Technical Data

M. Wt 1096.9
Formula C41H28N6Na4O17S4
Storage Desiccate at RT
CAS Number 111150-22-2
PubChem ID 16066783
InChI Key AQJHZNCSXLBXMY-UHFFFAOYSA-J
Smiles [Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC=C(NC(=O)C2=CC(=CC(NC(=O)NC3=CC(=CC(=C3)C(=O)NC3=CC=C(C=C3)S([O-])(=O)=O)C(=O)NC3=CC=C(C=C3)S([O-])(=O)=O)=C2)C(=O)NC2=CC=C(C=C2)S([O-])(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 43.88 40

Preparing Stock Solutions

The following data is based on the product molecular weight 1096.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 2.28 mL 11.4 mL 22.79 mL
2 mM 0.46 mL 2.28 mL 4.56 mL
4 mM 0.23 mL 1.14 mL 2.28 mL
20 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

View Related Products by Target

View Related Products by Product Action

View all Purinergic (P2X) Receptor Antagonists

Keywords: NF 110, NF 110 supplier, Potent, P2X3, antagonists, Receptors, Purinergic, purinoceptors, NF110, P2X, 2548, Tocris Bioscience

3 Citations for NF 110

Citations are publications that use Tocris products. Selected citations for NF 110 include:

Dosch et al (2019) Connexin-43-dependent ATP release mediates macrophage activation during sepsis. Elife 8 PMID: 30735126

Chandra et al (2019) Decoy Receptor Interactions as Novel Drug Targets against EKC-Causing Human Adenovirus. Viruses 11 PMID: 30870979

Nishimura et al (2015) The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog 11 e1005184 PMID: 26430888


Do you know of a great paper that uses NF 110 from Tocris? Please let us know.

Reviews for NF 110

There are currently no reviews for this product. Be the first to review NF 110 and earn rewards!

Have you used NF 110?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
P2X and P2Y Receptors

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.