Nelfinavir mesylate

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Cat.No. 3766 - Nelfinavir mesylate | C32H45N3O4S.CH4O3S | CAS No. 159989-65-8
Description: Potent HIV-1 protease inhibitor
Alternative Names: AG 1341
Chemical Name: (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2- hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (Ki = 2 nM) in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 663.89
Formula C32H45N3O4S.CH4O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 159989-65-8
PubChem ID 64142
InChI Key NQHXCOAXSHGTIA-SKXNDZRYSA-N
Smiles [H][C@]12CCCC[C@]([H])1C[C@@H]([C@@](NC(C)(C)C)=O)N(C[C@@H](O)[C@H](CSC3=CC=CC=C3)NC(C4=C(C)C(O)=CC=C4)=O)C2.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 66.39 100
ethanol 66.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 663.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.51 mL 7.53 mL 15.06 mL
5 mM 0.3 mL 1.51 mL 3.01 mL
10 mM 0.15 mL 0.75 mL 1.51 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Shetty et al (1996) Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease. Antimicrob.Agents Chemother. 40 110 PMID: 8787890

Patick et al (1996) Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob.Agents Chemother. 40 29 PMID: 8787874

Gills et al (2007) Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo. Clin.Cancer Res. 13 5183 PMID:


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Citations for Nelfinavir mesylate

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  • 7-TM Receptors
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  • Apoptosis
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