Nelfinavir mesylate

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Description: Potent HIV-1 protease inhibitor
Alternative Names: AG 1341
Chemical Name: (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2- hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Nelfinavir mesylate

Nelfinavir mesylate is an orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (Ki = 2 nM) in vitro. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.08 μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Nelfinavir mesylate

M. Wt 663.89
Formula C32H45N3O4S.CH4O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 159989-65-8
PubChem ID 64142
InChI Key NQHXCOAXSHGTIA-SKXNDZRYSA-N
Smiles [H][C@]12CCCC[C@]([H])1C[C@@H]([C@@](NC(C)(C)C)=O)N(C[C@@H](O)[C@H](CSC3=CC=CC=C3)NC(C4=C(C)C(O)=CC=C4)=O)C2.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nelfinavir mesylate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 66.39 100
ethanol 66.39 100

Preparing Stock Solutions for Nelfinavir mesylate

The following data is based on the product molecular weight 663.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.51 mL 7.53 mL 15.06 mL
5 mM 0.3 mL 1.51 mL 3.01 mL
10 mM 0.15 mL 0.75 mL 1.51 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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Product Datasheets for Nelfinavir mesylate

Certificate of Analysis / Product Datasheet
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References for Nelfinavir mesylate

References are publications that support the biological activity of the product.

Shetty et al (1996) Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease. Antimicrob.Agents Chemother. 40 110 PMID: 8787890

Patick et al (1996) Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob.Agents Chemother. 40 29 PMID: 8787874

Gills et al (2007) Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo. Clin.Cancer Res. 13 5183

Musarrat et al (2020) The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections. J.Med.Virol. 92 2087 PMID: 32374457

Ko et al (2021) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 13 PMID: 33918958


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1 Citation for Nelfinavir mesylate

Citations are publications that use Tocris products. Selected citations for Nelfinavir mesylate include:

Vladimir et al (2020) The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections. J Med Virol 92 2087-2095 PMID: 32374457


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