Nelfinavir mesylate

Pricing Availability   Qty
Cat.No. 3766 - Nelfinavir mesylate | C32H45N3O4S.CH4O3S | CAS No. 159989-65-8
Description: Potent HIV-1 protease inhibitor
Alternative Names: AG 1341
Chemical Name: (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2- hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (Ki = 2 nM) in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 663.89
Formula C32H45N3O4S.CH4O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 159989-65-8
PubChem ID 64142
InChI Key NQHXCOAXSHGTIA-SKXNDZRYSA-N
Smiles [H][C@]12CCCC[C@]([H])1C[C@@H]([C@@](NC(C)(C)C)=O)N(C[C@@H](O)[C@H](CSC3=CC=CC=C3)NC(C4=C(C)C(O)=CC=C4)=O)C2.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 66.39 100
ethanol 66.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 663.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.51 mL 7.53 mL 15.06 mL
5 mM 0.3 mL 1.51 mL 3.01 mL
10 mM 0.15 mL 0.75 mL 1.51 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Shetty et al (1996) Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease. Antimicrob.Agents Chemother. 40 110 PMID: 8787890

Patick et al (1996) Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob.Agents Chemother. 40 29 PMID: 8787874

Gills et al (2007) Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo. Clin.Cancer Res. 13 5183


If you know of a relevant reference for Nelfinavir mesylate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Protease Inhibitors

Keywords: Nelfinavir mesylate, Nelfinavir mesylate supplier, Orally, active, human, immunodeficiency, virus, proteases, inhibitors, Potent, inhibits, HIV-1, HIV1, HIV, AG1341, AG, 1341, Pfizer, Other, Proteases, Antivirals, 3766, Tocris Bioscience

Citations for Nelfinavir mesylate

Citations are publications that use Tocris products.

Currently there are no citations for Nelfinavir mesylate. Do you know of a great paper that uses Nelfinavir mesylate from Tocris? Please let us know.

Reviews for Nelfinavir mesylate

There are currently no reviews for this product. Be the first to review Nelfinavir mesylate and earn rewards!

Have you used Nelfinavir mesylate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells