NE 100 hydrochloride

Pricing Availability   Qty
Description: Selective σ1 antagonist
Chemical Name: 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews (1)

Biological Activity for NE 100 hydrochloride

NE 100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.

Compound Libraries for NE 100 hydrochloride

NE 100 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NE 100 hydrochloride

M. Wt 391.97
Formula C23H33NO2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 149409-57-4
PubChem ID 9952420
InChI Key ZHGMDXSHODHWHV-UHFFFAOYSA-N
Smiles CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NE 100 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.8 25
DMSO 39.2 100

Preparing Stock Solutions for NE 100 hydrochloride

The following data is based on the product molecular weight 391.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.76 mL 25.51 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets for NE 100 hydrochloride

Certificate of Analysis / Product Datasheet
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References for NE 100 hydrochloride

References are publications that support the biological activity of the product.

Chaki et al (1994) NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain. Eur.J.Pharmacol. 251 R1 PMID: 8137864

Okuyama et al (1993) NE-100, a novel sigma receptor ligand: in vivo tests. Pharmacol.Letts. 53 PL285

Tanaka et al (1995) Characteristics of binding of [3H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes. Naunyn Schmied.Arch.Pharmacol. 351 244


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Keywords: NE 100 hydrochloride, NE 100 hydrochloride supplier, Selective, σ1, sigma1, antagonists, Receptors, NE100, Sigma1, 3133, Tocris Bioscience

8 Citations for NE 100 hydrochloride

Citations are publications that use Tocris products. Selected citations for NE 100 hydrochloride include:

Song et al (2022) Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat.Card.Res. 1 142 PMID: 36051854

Morató et al (2023) Development of a novel σ1 receptor biosensor based on its heterodimerization with binding immunoglobulin protein in living cells. ACS Chem.Neurosci. PMID: 37191585

Rodríguez-Muñoz et al (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Br J Pharmacol 6 35458 PMID: 26461475

Malik et al (2015) The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. Int J Neuropsychopharmacol 172 2519 PMID: 25573298


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Reviews for NE 100 hydrochloride

Average Rating: 3 (Based on 1 Review.)

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It can inhibit sigma1 receptor.
By Yuyang Sun on 06/29/2022
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: sh-sy5y

Used it to inhibit sigma 1 receptors. It can inhibit sigma 1 receptor and increase SOCE channels.

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