NDT 30805

Pricing Availability   Qty
Description: Potent NLRP3 inflammasome inhibitor
Chemical Name: 2-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino)-5-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7(4H)-thione
Purity: ≥95% (HPLC)

Biological Activity for NDT 30805

NDT 30805 is a potent NLRP3 inflammasome inhibitor. Inhibits IL-1β release in peripheral blood mononuclear cell assay, ASC speck assay and in whole blood (IC50 values are 13 nM, 34 nM and 1500 nM). Inhibits Nigericin (Cat. No. 4312) and ATP-induced IL-1β release. Soluble and uncharged at physiological pH.

Technical Data for NDT 30805

M. Wt 414.53
Formula C23H22N6S
Storage Store at -20°C
Purity ≥95% (HPLC)
PubChem ID 164946940
Smiles S=C(C=C(CC1=NC=CC=C1)N2)N(C2=N3)N=C3NC4=C5C(CCC5)=CC6=C4CCC6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NDT 30805

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.45 100

Preparing Stock Solutions for NDT 30805

The following data is based on the product molecular weight 414.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.06 mL 24.12 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for NDT 30805

References are publications that support the biological activity of the product.

Harrison et al (2022) Discovery and optimization of triazolopyrimidinone derivatives as selective NLRP3 inflammasome inhibitors. ACS Med.Chem.Lett. 13 1321 PMID: 35978696

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Citations for NDT 30805

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