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Biological Activity for NCS-382
NCS-382 is a γ-Hydroxybutyric acid antagonist, anticonvulsant.
Technical Data for NCS-382
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NCS-382
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NCS-382
The following data is based on the product molecular weight 218.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.58 mL||22.91 mL||45.82 mL|
|5 mM||0.92 mL||4.58 mL||9.16 mL|
|10 mM||0.46 mL||2.29 mL||4.58 mL|
|50 mM||0.09 mL||0.46 mL||0.92 mL|
Product Datasheets for NCS-382
References for NCS-382
References are publications that support the biological activity of the product.
King et al (1997) Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice. J.Neural Transm. 104 1177 PMID: 9503264
Maitre et al (1990) A specific γ-hydroxybutyrate receptor ligand possesses both antagonist and anticonvulsant properties. J.Pharmacol.Exp.Ther. 255 657 PMID: 2173754
Schmidt et al (1991) Anti-sedative and anti-cataleptic properties of NCS-382, a γ-hydroxybutyrate receptor antagonist. Eur.J.Pharmacol. 203 393 PMID: 1773824
If you know of a relevant reference for NCS-382, please let us know.
Keywords: NCS-382, NCS-382 supplier, antagonists, γ-hydroxybutyric, gamma-hydroxybutyric, acid, GABAA, GABAC, Receptors, GABAB, anticonvulsant, Miscellaneous, GABA, 0780, Tocris Bioscience
Citations for NCS-382
Citations are publications that use Tocris products.
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Literature in this Area
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GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.