NCS-382

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Cat.No. 0780 - NCS-382 | C13H14O3 | CAS No. 520505-01-5
Description: Antagonist of γ-hydroxybutyric acid
Chemical Name: 6,7,8,9-Tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylideneacetic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

γ-Hydroxybutyric acid antagonist, anticonvulsant.

Technical Data

M. Wt 218.25
Formula C13H14O3
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 520505-01-5
PubChem ID 5875451
InChI Key UADPGHINQMWEAG-CSKARUKUSA-N
Smiles OC1C2=C(CCC\C1=C/C(O)=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 218.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.58 mL 22.91 mL 45.82 mL
5 mM 0.92 mL 4.58 mL 9.16 mL
10 mM 0.46 mL 2.29 mL 4.58 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

King et al (1997) Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice. J.Neural Transm. 104 1177 PMID: 9503264

Maitre et al (1990) A specific γ-hydroxybutyrate receptor ligand possesses both antagonist and anticonvulsant properties. J.Pharmacol.Exp.Ther. 255 657 PMID: 2173754

Schmidt et al (1991) Anti-sedative and anti-cataleptic properties of NCS-382, a γ-hydroxybutyrate receptor antagonist. Eur.J.Pharmacol. 203 393 PMID: 1773824


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Keywords: NCS-382, supplier, antagonists, γ-hydroxybutyric, gamma-hydroxybutyric, acid, GABAA, GABAC, Receptors, GABAB, anticonvulsant, Miscellaneous, GABA, Tocris Bioscience

Citations for NCS-382

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Literature in this Area

GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Pathways for NCS-382

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