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Cat.No. 0780 - NCS-382 | C13H14O3 | CAS No. 520505-01-5
Description: Antagonist of γ-hydroxybutyric acid
Chemical Name: 6,7,8,9-Tetrahydro-5-hydroxy-5H-benzocyclohept-6-ylideneacetic acid
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for NCS-382

NCS-382 is a γ-Hydroxybutyric acid antagonist, anticonvulsant.

Technical Data for NCS-382

M. Wt 218.25
Formula C13H14O3
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 520505-01-5
PubChem ID 5875451
Smiles OC1C2=C(CCC\C1=C/C(O)=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NCS-382

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.83 100

Preparing Stock Solutions for NCS-382

The following data is based on the product molecular weight 218.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.58 mL 22.91 mL 45.82 mL
5 mM 0.92 mL 4.58 mL 9.16 mL
10 mM 0.46 mL 2.29 mL 4.58 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets for NCS-382

Certificate of Analysis is currently unavailable on-line.
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References for NCS-382

References are publications that support the biological activity of the product.

King et al (1997) Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice. J.Neural Transm. 104 1177 PMID: 9503264

Maitre et al (1990) A specific γ-hydroxybutyrate receptor ligand possesses both antagonist and anticonvulsant properties. J.Pharmacol.Exp.Ther. 255 657 PMID: 2173754

Schmidt et al (1991) Anti-sedative and anti-cataleptic properties of NCS-382, a γ-hydroxybutyrate receptor antagonist. Eur.J.Pharmacol. 203 393 PMID: 1773824

If you know of a relevant reference for NCS-382, please let us know.

Keywords: NCS-382, NCS-382 supplier, antagonists, γ-hydroxybutyric, gamma-hydroxybutyric, acid, GABAA, GABAC, Receptors, GABAB, anticonvulsant, Miscellaneous, GABA, 0780, Tocris Bioscience

Citations for NCS-382

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GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.