NCH 51

Pricing Availability Delivery Time Qty
Cat.No. 3747 - NCH 51 | C20H26N2O2S2 | CAS No. 848354-66-5
Description: Histone deacetylase inhibitor
Alternative Names: PTACH
Chemical Name: 2-Methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Histone deacetylase (HDAC) inhibitor. Inhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1 μM).

Technical Data

M. Wt 390.56
Formula C20H26N2O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 848354-66-5
PubChem ID 11395181
InChI Key MDYDGUOQFUQOGE-UHFFFAOYSA-N
Smiles O=C(CCCCCCSC(C(C)C)=O)NC1=NC(C2=CC=CC=C2)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.06 100
ethanol 9.76 25

Preparing Stock Solutions

The following data is based on the product molecular weight 390.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.8 mL 25.6 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the biological activity of the product.

Suzuki et al (2005) Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J.Med.Chem. 48 1019 PMID: 15715470

Sanda et al (2007) Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. Leukemia 21 2344 PMID: 17690692


If you know of a relevant reference for NCH 51, please let us know.

View Related Products by Product Action

View all Non-selective Histone Deacetylase Inhibitors

Keywords: NCH 51, NCH 51 supplier, NCH51, HDACs, inhibitors, inhibits, histone, deacetylases, epigenetics, PTACH, Non-selective, Non-Selective, 3747, Tocris Bioscience

Citations for NCH 51

Citations are publications that use Tocris products.

Currently there are no citations for NCH 51. Do you know of a great paper that uses NCH 51 from Tocris? Please let us know.

Reviews for NCH 51

There are currently no reviews for this product. Be the first to review NCH 51 and earn rewards!

Have you used NCH 51?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
Rheumatoid Arthritis

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.