NBQX disodium salt

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Description: Potent AMPA antagonist; more water soluble form of NBQX (Cat. No. 0373)
Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (42)
Reviews (3)
Literature (5)

Biological Activity for NBQX disodium salt

NBQX disodium salt is a selective and competitive AMPA and kainate receptor antagonist (IC50 = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.

NBQX disodium salt is a more water-soluble form of NBQX (Cat. No. 0373).

Licensing Information

Sold with the permission of Novo Nordisk A/S

Technical Data for NBQX disodium salt

M. Wt 380.24
Formula C12H6N4O6SNa2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 479347-86-9
PubChem ID 3272523
InChI Key SVJKYIUJRJEABK-UHFFFAOYSA-L
Smiles [Na+].[Na+].NS(=O)(=O)C1=C2C(=CC=C1)C1=NC([O-])=C([O-])N=C1C=C2[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NBQX disodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 38.02 100

Preparing Stock Solutions for NBQX disodium salt

The following data is based on the product molecular weight 380.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.15 mL 26.3 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets for NBQX disodium salt

Certificate of Analysis / Product Datasheet
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References for NBQX disodium salt

References are publications that support the biological activity of the product.

Gill et al (1992) The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 580 35 PMID: 1504814

Namba et al (1994) Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 638 36 PMID: 8199874

Sheardown et al (1993) The pharmacology of AMPA receptors and their antagonists. Stroke 24 146 PMID: 7504337

Zeman and Lodg (1992) Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 106 367 PMID: 1382781

Yoon et al (2005) Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test J.Korean Med.Sci. 20 307 PMID: 15832006


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Keywords: NBQX disodium salt, NBQX disodium salt supplier, water, soluble, NBQX, Glutamate, AMPA, Receptors, iGlu, Ionotropic, antagonists, 1044, Tocris Bioscience

42 Citations for NBQX disodium salt

Citations are publications that use Tocris products. Selected citations for NBQX disodium salt include:

Xiao et al (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife 7 PMID: 29676731

Purkey et al (2018) AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell Rep 25 974 PMID: 30355502

Kiritoshi and Neugebauer (2018) Pathway-specific alterations of cortico-amygdala transmission in an arthritis pain model. ACS Chem Neurosci 9 2252 PMID: 29630339

Butti et al (2012) Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain 135 3320 PMID: 23008234

Zheng et al (2010) SAP102 is a highly mobile MAGUK in spines. J Neurosci 30 4757 PMID: 20357126

Kopach et al (2022) Multi-target action of β-alanine protects cerebellar tissue from ischemic damage. Cell Death Dis 13 747 PMID: 36038575

Bortone et al (2014) Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex. J Neurosci 82 474 PMID: 24656931

Bloodgood et al (2013) The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature 503 121 PMID: 24201284

O'Malley et al (2020) TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations J Neurosci 40 4813 PMID: 32414784

Tikidji-Hamburyan et al (2017) Rods progressively escape saturation to drive visual responses in daylight conditions. Nat Commun 8 1813 PMID: 29180667

Kim and Cho (2017) Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala. Neuron 95 1129 PMID: 28823727

Xiao et al (2017) Biased OXTergic Modulation of Midbrain DA Systems. Neuron 95 368 PMID: 28669546

Li et al (2017) A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex. Neuron 94 1155 PMID: 28641114

Sigler et al (2017) Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release. Neuron 94 304 PMID: 28426965

Kramer et al (2020) Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release. ELife 9 PMID: 32870779

Bocchio et al (2020) Hippocampal hub neurons maintain distinct connectivity throughout their lifetime. Nat Commun 11 4559 PMID: 32917906

Evans et al (2020) Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons. Cell Rep 32 PMID: 32937133

Tsutsui-Kimura et al (2015) Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex. Neuron 18 PMID: 25522418

Liu et al (2015) Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output. Sci Rep 35 5680 PMID: 25855181

Malvaez et al (2015) Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions. PLoS One 5 12511 PMID: 26212790

Ronesi et al (2004) Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport. J Neurosci 24 1673 PMID: 14973237

Hull (2017) Measuring Feedforward Inhibition and Its Impact on Local Circuit Function. Cold Spring Harb Protoc 2017 PMID: 28461661

Liu et al (2016) Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour. Nature 538 383 PMID: 27732573

O'Donnell et al (2016) Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. J Neurosci 36 7109 PMID: 27383588

Maldonado et al (2021) Oxytocin shapes spontaneous activity patterns in the developing visual cortex by activating somatostatin interneurons. Curr Biol 31 322 PMID: 33157028

Harkany et al (2004) Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. PLoS One 24 4978 PMID: 15163690

Liu et al (2004) Astrocyte-mediated activation of neuronal kainate receptors. Nature 101 3172 PMID: 14766987

Lai et al (2017) Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18. Neuron 95 591 PMID: 28772123

Shin et al (2006) Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab 26 1018 PMID: 16340958

Gensel et al (2012) Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury. J Neurosci 7 e33519 PMID: 22428066

Olsen et al (2012) Gain control by layer six in cortical circuits of vision. J Neurophysiol 483 47 PMID: 22367547

Fan et al (2018) All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nat Methods 15 823 PMID: 30275587

Chang and Higley (2018) Potassium channels contribute to activity-dependent regulation of dendritic inhibition. Physiol Rep 6 e13747 PMID: 29939492

Carlson et al (2012) Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica. Brain Behav 2 391 PMID: 22950043

Reinhard et al (2014) Step-by-step instructions for retina recordings with perforated multi electrode arrays. PLoS One 9 e106148 PMID: 25165854

Crook et al (2014) A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina. Vis Neurosci 31 57 PMID: 24801624

He et al (2013) Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-MthD.-aspartate receptor inhibition. Int J Neuropsychopharmacol 109 1535 PMID: 23255721

Maeder et al (2018) The THO Complex Coordinates Transcripts for Synapse Development and DA Neuron Survival. Cell 174 1436 PMID: 30146163

Sancho and Bloodgood (2018) Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex. Cell Rep 24 2075 PMID: 30134169

Beas et al (2018) The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism. Nat Neurosci 21 963 PMID: 29915192

Collins et al (2018) Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. Neuron 98 366 PMID: 29628187

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Neurochem Int 10 e0131430 PMID: 26102354


Do you know of a great paper that uses NBQX disodium salt from Tocris? Please let us know.

Reviews for NBQX disodium salt

Average Rating: 5 (Based on 3 Reviews.)

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Suppression of AMPA receptors.
By Anonymous on 06/21/2023
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Cerebellum

NBQX disodium salt was used as a control to demonstrate pharmacological isolation of AMPAR-generated whole-cell electrophysiological response. Top trace: response to rapidly applied AMPA. Bottom trace: response to AMPA+NBQX.

Needs sonication for dilution

review image

The best option to block AMPA receptors.
By Luiz Alexandre Magno on 06/20/2018
Assay Type: In Vivo
Species: Mouse

I infused the NBQX disodium salt (22 mM) into mouse brain to block AMPA receptors in the striatum. This was done by using an internal infusion cannula. The disodium salt is the best choice for this kind of experiment because it is soluble in aqueous solutions such as NaCl 0.9%. NBQX is more specific and potent than DNQX.

Always make fresh solutions

PMID: 28436980

Excellent AMPA receptor antagonist.
By Andy Gao on 01/13/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Hippocampus

Used in extracellular bath solution during electrophysiology of hippocampal neuron culture to block glutamatergic AMPA receptors to isolate NMDA receptor currents.

Aliquot properly in dMSO

review image

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