NBQX disodium salt

Pricing Availability Delivery Time Qty
Cat.No. 1044 - NBQX disodium salt | C12H6N4O6SNa2 | CAS No. 479347-86-9
Description: Potent AMPA antagonist. More water soluble form of NBQX (Cat. No. 0373)
Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (16)
Literature

Biological Activity

Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo. More water soluble disodium salt of NBQX (Cat. No. 0373). Also available as part of the AMPA Receptor Tocriset™.

Licensing Information

Sold with the permission of Novo Nordisk A/S

Technical Data

M. Wt 380.24
Formula C12H6N4O6SNa2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 479347-86-9
PubChem ID 3272523
InChI Key SVJKYIUJRJEABK-UHFFFAOYSA-L
Smiles [Na+].[Na+].NS(=O)(=O)C1=C2C(=CC=C1)C1=NC([O-])=C([O-])N=C1C=C2[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 38.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 380.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.15 mL 26.3 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gill et al (1992) The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 580 35 PMID: 1504814

Namba et al (1994) Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 638 36 PMID: 8199874

Sheardown et al (1993) The pharmacology of AMPA receptors and their antagonists. Stroke 24 146 PMID: 7504337

Zeman and Lodg (1992) Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 106 367 PMID: 1382781


If you know of a relevant reference for NBQX disodium salt, please let us know.

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Keywords: water soluble NBQX Glutamate AMPA Receptors iGlu Ionotropic antagonists AMPA Receptors

16 Citations for NBQX disodium salt

Citations are publications that use Tocris products. Selected citations for NBQX disodium salt include:

Olsen et al (2012) Gain control by layer six in cortical circuits of vision. J Neurophysiol 483 47 PMID: 22367547

Gensel et al (2012) Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury. J Neurosci 7 e33519 PMID: 22428066

Zheng et al (2010) SAP102 is a highly mobile MAGUK in spines. J Neurosci 30 4757 PMID: 20357126

Shin et al (2006) Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab 26 1018 PMID: 16340958

Liu et al (2004) Astrocyte-mediated activation of neuronal kainate receptors. Nature 101 3172 PMID: 14766987

Harkany et al (2004) Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. PLoS One 24 4978 PMID: 15163690

Tsutsui-Kimura et al (2015) Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex. Neuron 18 PMID: 25522418

Liu et al (2015) Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output. Sci Rep 35 5680 PMID: 25855181

Malvaez et al (2015) Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions. PLoS One 5 12511 PMID: 26212790

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Neurochem Int 10 e0131430 PMID: 26102354

Reinhard et al (2014) Step-by-step instructions for retina recordings with perforated multi electrode arrays. PLoS One 9 e106148 PMID: 25165854

Crook et al (2014) A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina. Vis Neurosci 31 57 PMID: 24801624

Bortone et al (2014) Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex. J Neurosci 82 474 PMID: 24656931

Bloodgood et al (2013) The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature 503 121 PMID: 24201284

He et al (2013) Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition. Int J Neuropsychopharmacol 109 1535 PMID: 23255721

Butti et al (2012) Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain 135 3320 PMID: 23008234


Do you know of a great paper that uses NBQX disodium salt from Tocris? If so please let us know.

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