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Biological Activity for NBC 6
NBC 6 is a NLRP3 inflammasome inhibitor (IC50 = 574 nM). Inhibits nigericin-induced inflammasome activation in THP-1 cells and Imiquimod (Cat. No. 3700) induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).
Sold under license from the University of Manchester.
Technical Data for NBC 6
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NBC 6
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NBC 6
The following data is based on the product molecular weight 409.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.44 mL||12.21 mL||24.42 mL|
|5 mM||0.49 mL||2.44 mL||4.88 mL|
|10 mM||0.24 mL||1.22 mL||2.44 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
References for NBC 6
References are publications that support the biological activity of the product.
Baldwin et al (2017) Boron-based inhibitors of the NLRP3 inflammasome. Cell Chem.Biol. 24 1321 PMID: 28943355
If you know of a relevant reference for NBC 6, please let us know.
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Keywords: NBC 6, NBC 6 supplier, NBC6, inflammasome, inhibitors, inhibits, NLRP3, Inflammasomes, 6925, Tocris Bioscience
Citations for NBC 6
Citations are publications that use Tocris products.
Currently there are no citations for NBC 6. Do you know of a great paper that uses NBC 6 from Tocris? Please let us know.
Reviews for NBC 6
Average Rating: 5 (Based on 1 Review.)
Have you used NBC 6?
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We ordered this product, combining with another pyroptosis inhibitor NSA, to confirm the induction of pyroptosis by staphylococcal virulence factors. We have shown that NSA significantly inhibited the release of LDH by THP-1 cells treated with staphylococcal products. To confirm that tested staphylococcal product induces pyroptosis, we also used 20 uM NBC 6 to pretreat THP-1 cells before incubating with staphylococcal product. Similarly, treatment of THP-1 cells with NBC 6 also significantly decreased the release of LDH in THP-1 cells treated by staphylococcal product.
Literature in this Area
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