NBC 6

Pricing Availability   Qty
Cat.No. 6925 - NBC 6 | C18H16BCl3N2O2 | CAS No. 2068818-02-8
Description: NLRP3 inflammasome inhibitor
Chemical Name: (T4)-[2-Acetyl-4,4,4-trichloro-3-(imino-κN)butanamidito-κO]diphenylboron
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (4)

Biological Activity

NLRP3 inflammasome inhibitor (IC50 = 574 nM). Inhibits nigericin-induced inflammasome activation in THP-1 cells and Imiquimod (Cat. No. 3700) induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

Licensing Information

Sold under license from the University of Manchester.

Technical Data

M. Wt 409.5
Formula C18H16BCl3N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2068818-02-8
PubChem ID 145237739
InChI Key VKECODDKRKQJNM-UHFFFAOYSA-N
Smiles CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.95 100
ethanol 2.05 5

Preparing Stock Solutions

The following data is based on the product molecular weight 409.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Baldwin et al (2017) Boron-based inhibitors of the NLRP3 inflammasome. Cell Chem.Biol. 24 1321 PMID: 28943355


If you know of a relevant reference for NBC 6, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Inflammasomes Inhibitors

Keywords: NBC 6, NBC 6 supplier, NBC6, inflammasome, inhibitors, inhibits, NLRP3, Inflammasomes, 6925, Tocris Bioscience

Citations for NBC 6

Citations are publications that use Tocris products.

Currently there are no citations for NBC 6. Do you know of a great paper that uses NBC 6 from Tocris? Please let us know.

Reviews for NBC 6

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used NBC 6?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


NBC 6 can efficiently block pyroptosis induction.
By Xiaogang Wang on 06/12/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: THP-1 cells

We ordered this product, combining with another pyroptosis inhibitor NSA, to confirm the induction of pyroptosis by staphylococcal virulence factors. We have shown that NSA significantly inhibited the release of LDH by THP-1 cells treated with staphylococcal products. To confirm that tested staphylococcal product induces pyroptosis, we also used 20 uM NBC 6 to pretreat THP-1 cells before incubating with staphylococcal product. Similarly, treatment of THP-1 cells with NBC 6 also significantly decreased the release of LDH in THP-1 cells treated by staphylococcal product.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling