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Description: NLRP3 inflammasome inhibitor
Chemical Name: (T4)-[2-Acetyl-4,4,4-trichloro-3-(imino-κN)butanamidito-κO]diphenylboron
Purity: ≥98% (HPLC)
Reviews (1)

Biological Activity for NBC 6

NBC 6 is a NLRP3 inflammasome inhibitor (IC50 = 574 nM). Inhibits nigericin-induced inflammasome activation in THP-1 cells and Imiquimod (Cat. No. 3700) induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

Licensing Information

Sold under license from the University of Manchester.

Technical Data for NBC 6

M. Wt 409.5
Formula C18H16BCl3N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2068818-02-8
PubChem ID 145237739
Smiles CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NBC 6

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.95 100
ethanol 2.05 5

Preparing Stock Solutions for NBC 6

The following data is based on the product molecular weight 409.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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References for NBC 6

References are publications that support the biological activity of the product.

Baldwin et al (2017) Boron-based inhibitors of the NLRP3 inflammasome. Cell Chem.Biol. 24 1321 PMID: 28943355

If you know of a relevant reference for NBC 6, please let us know.

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Keywords: NBC 6, NBC 6 supplier, NBC6, inflammasome, inhibitors, inhibits, NLRP3, Inflammasomes, 6925, Tocris Bioscience

Citations for NBC 6

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Reviews for NBC 6

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NBC 6 can efficiently block pyroptosis induction.
By Xiaogang Wang on 06/12/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: THP-1 cells

We ordered this product, combining with another pyroptosis inhibitor NSA, to confirm the induction of pyroptosis by staphylococcal virulence factors. We have shown that NSA significantly inhibited the release of LDH by THP-1 cells treated with staphylococcal products. To confirm that tested staphylococcal product induces pyroptosis, we also used 20 uM NBC 6 to pretreat THP-1 cells before incubating with staphylococcal product. Similarly, treatment of THP-1 cells with NBC 6 also significantly decreased the release of LDH in THP-1 cells treated by staphylococcal product.

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