Imiquimod

Pricing Availability Delivery Time Qty
Cat.No. 3700 - Imiquimod | C14H16N4 | CAS No. 99011-02-6
Description: Toll-like receptor 7 (TLR7) agonist
Alternative Names: R 837
Chemical Name: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Immunomodulator that displays antiviral and antitumor activity. Acts as a Toll-like receptor 7 (TLR7) agonist; stimulates proinflammatory cytokine production and activates NF-κB.

Technical Data

M. Wt 240.3
Formula C14H16N4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 99011-02-6
PubChem ID 57469
InChI Key DOUYETYNHWVLEO-UHFFFAOYSA-N
Smiles CC(C)CN2C=NC1=C(N)N=C3C(C=CC=C3)=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.2 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 240.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.16 mL 20.81 mL 41.61 mL
5 mM 0.83 mL 4.16 mL 8.32 mL
10 mM 0.42 mL 2.08 mL 4.16 mL
50 mM 0.08 mL 0.42 mL 0.83 mL

Molarity Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Schon and Schon (2007) The antitumoral mode of action of imiquimod and other imidazoquinolines. Curr.Med.Chem. 14 681 PMID: 17346155

Averett et al (2007) The pharmacology of endosomal TLR agonists in viral disease. Biochem.Soc.Trans. 35 1468 PMID: 18031247

Syed et al (2001) A review of the applications of imiquimod: a novel immune response modifier. Exp.Opin.Pharmacother. 2 877 PMID:


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Citations for Imiquimod

Citations are publications that use Tocris products.

Currently there are no citations for Imiquimod. Do you know of a great paper that uses Imiquimod from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for Imiquimod

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.

Protocols

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