Pricing Availability   Qty
Description: Toll-like receptor 7 (TLR7) agonist
Alternative Names: R 837
Chemical Name: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
Purity: ≥99% (HPLC)
Citations (4)
Literature (1)
Pathways (1)

Biological Activity for Imiquimod

Imiquimod is an immunomodulator that displays antiviral and antitumor activity. Acts as a Toll-like receptor 7 (TLR7) agonist; stimulates proinflammatory cytokine production and activates NF-κB.

Technical Data for Imiquimod

M. Wt 240.3
Formula C14H16N4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 99011-02-6
PubChem ID 57469
Smiles CC(C)CN2C=NC1=C(N)N=C3C(C=CC=C3)=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Imiquimod

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 1.2 5 with gentle warming

Preparing Stock Solutions for Imiquimod

The following data is based on the product molecular weight 240.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 83.23 mL 416.15 mL 832.29 mL
0.25 mM 16.65 mL 83.23 mL 166.46 mL
0.5 mM 8.32 mL 41.61 mL 83.23 mL
2.5 mM 1.66 mL 8.32 mL 16.65 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Imiquimod

References are publications that support the biological activity of the product.

Schon and Schon (2007) The antitumoral mode of action of imiq. and other imidazoquinolines. Curr.Med.Chem. 14 681 PMID: 17346155

Averett et al (2007) The pharmacology of endosomal TLR agonists in viral disease. Biochem.Soc.Trans. 35 1468 PMID: 18031247

Syed et al (2001) A review of the applications of imiquimod: a novel immune response modifier. Exp.Opin.Pharmacother. 2 877

If you know of a relevant reference for Imiquimod, please let us know.

View Related Products by Product Action

View all Toll-like Receptor Agonists

Keywords: Imiquimod, Imiquimod supplier, Toll-like, receptors, 7, TLR7, agonists, R837, R, 837, Receptors, Non-selective, Antivirals, 3700, Tocris Bioscience

4 Citations for Imiquimod

Citations are publications that use Tocris products. Selected citations for Imiquimod include:

Zoltan et al (2022) Presence of TRPA1 Modifies CD4+/CD8+ T Lymphocyte Ratio and Activation. Pharmaceuticals (Basel) 15 PMID: 35056114

Jian et al (2021) Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis. Nat Commun 12 4546 PMID: 34315884

Qian et al (2020) Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip. Elife 9 PMID: 32096759

Erick M et al (2020) Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways. Cell Rep 30 4399-4417.e7 PMID: 32234476

Do you know of a great paper that uses Imiquimod from Tocris? Please let us know.

Reviews for Imiquimod

There are currently no reviews for this product. Be the first to review Imiquimod and earn rewards!

Have you used Imiquimod?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Imiquimod

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.