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Imiquimod is an immunomodulator that displays antiviral and antitumor activity. Acts as a Toll-like receptor 7 (TLR7) agonist; stimulates proinflammatory cytokine production and activates NF-κB.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||1.2||5 with gentle warming|
The following data is based on the product molecular weight 240.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||83.23 mL||416.15 mL||832.29 mL|
|0.25 mM||16.65 mL||83.23 mL||166.46 mL|
|0.5 mM||8.32 mL||41.61 mL||83.23 mL|
|2.5 mM||1.66 mL||8.32 mL||16.65 mL|
References are publications that support the biological activity of the product.
Schon and Schon (2007) The antitumoral mode of action of imiq. and other imidazoquinolines. Curr.Med.Chem. 14 681 PMID: 17346155
Averett et al (2007) The pharmacology of endosomal TLR agonists in viral disease. Biochem.Soc.Trans. 35 1468 PMID: 18031247
Syed et al (2001) A review of the applications of imiquimod: a novel immune response modifier. Exp.Opin.Pharmacother. 2 877
If you know of a relevant reference for Imiquimod, please let us know.
Keywords: Imiquimod, Imiquimod supplier, Toll-like, receptors, 7, TLR7, agonists, R837, R, 837, Receptors, Non-selective, Antivirals, 3700, Tocris Bioscience
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