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Description: Potent NLRP3 inflammasome inhibitor
Chemical Name: (T4)-[2-Acetyl-4,4,4-trichloro-N-cyclohexyl-3-(imino-κN)butanamidato-κO]diphenylboron
Purity: ≥98% (HPLC)
Biological Activity for NBC 19
NBC 19 is a potent NLRP3 inflammasome inhibitor (IC50 = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release.
Licensing Information
Sold under license from the University of Manchester.
Technical Data for NBC 19
| M. Wt | 491.64 |
| Formula | C24H26BCl3N2O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2068818-75-5 |
| InChI Key | XLUPBOKHLVUFLX-UHFFFAOYSA-N |
| Smiles | CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1NC4CCCCC4)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NBC 19
References for NBC 19
References are publications that support the biological activity of the product.
Baldwin et al (2017) Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem.Biol. 24 1321 PMID: 28943355
Redondo-Castro et al (2018) Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Sci.Rep. 8 5667 PMID: 29618797
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Keywords: NBC 19, NBC 19 supplier, NBC19, Potent, NLRP3, inhibitors, inhibits, inflammasome, Inflammasomes, 6722, Tocris Bioscience
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