NBC 19

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Description: Potent NLRP3 inflammasome inhibitor
Chemical Name: (T4)-[2-Acetyl-4,4,4-trichloro-N-cyclohexyl-3-(imino-κN)butanamidato-κO]diphenylboron
Purity: ≥98% (HPLC)

Biological Activity for NBC 19

NBC 19 is a potent NLRP3 inflammasome inhibitor (IC50 = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release.

Licensing Information

Sold under license from the University of Manchester.

Technical Data for NBC 19

M. Wt 491.64
Formula C24H26BCl3N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2068818-75-5
Smiles CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1NC4CCCCC4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NBC 19

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.16 100
ethanol 49.16 100

Preparing Stock Solutions for NBC 19

The following data is based on the product molecular weight 491.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.17 mL 20.34 mL
5 mM 0.41 mL 2.03 mL 4.07 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References for NBC 19

References are publications that support the biological activity of the product.

Baldwin et al (2017) Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem.Biol. 24 1321 PMID: 28943355

Redondo-Castro et al (2018) Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Sci.Rep. 8 5667 PMID: 29618797

If you know of a relevant reference for NBC 19, please let us know.

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