Naproxen sodium

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Cat.No. 2655 - Naproxen sodium | C14H13NaO3 | CAS No. 26159-34-2
Description: Cyclooxygenase inhibitor
Chemical Name: (2S)-2-(6-Methoxy-2-naphthyl)propanoic acid sodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress.

Technical Data

M. Wt 252.24
Formula C14H13NaO3
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 26159-34-2
PubChem ID 23681059
InChI Key CDBRNDSHEYLDJV-FVGYRXGTSA-M
Smiles [Na+].COC1=CC=C2C=C(C=CC2=C1)[C@H](C)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 252.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.96 mL 19.82 mL 39.64 mL
5 mM 0.79 mL 3.96 mL 7.93 mL
10 mM 0.4 mL 1.98 mL 3.96 mL
50 mM 0.08 mL 0.4 mL 0.79 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sutton (1996) Naproxen sodium. J.Am.Pharm.Assoc. (Wash) NS36 633 PMID: 8952250

Dhir et al (2006) Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice. Eur.J.Pharmacol. 535 192 PMID: 16522321

Kumar et al (2006) Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. Eur.J.Pharmacol. 551 58 PMID: 17027965


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Keywords: Naproxen sodium, supplier, Cyclooxygenase, inhibitors, inhibits, COX, Oxygenases, Oxidases, oxidative, stress, Cyclooxygenase, Cyclooxygenase, Tocris Bioscience

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