Naloxonazine dihydrochloride

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Cat.No. 0591 - Naloxonazine dihydrochloride | C38H42N4O6.2HCl | CAS No. 880759-65-9
Description: Selective μ1 antagonist
Chemical Name: Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene] hydrazine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Potent opioid antagonist, selective for μ1 receptors.

Technical Data

M. Wt 723.69
Formula C38H42N4O6.2HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 880759-65-9
PubChem ID 90479735
InChI Key VIAIHLLKDJKEKM-JNHLASQBSA-N
Smiles OC(C(N(CC=C)CC%10)C6)7C2%10C1=C6C=CC(O)=C1OC2/C(CC7)=N/N=C3CCC8(O)C49C/3OC5=C(O)C=CC(CC8N(CC=C)CC9)=C45.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 25 mM in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Paul et al (1988) Differential blockade by naloxonazine of two μ opiate actions: analgesic and inhibition of gastrointestinal transit. Eur.J.Pharmacol. 149 403 PMID: 2842168


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Keywords: Naloxonazine dihydrochloride, Naloxonazine dihydrochloride supplier, Selective, antagonists, μ-opioid, mu-opioid, μ1-opioid, mu1-opioid, MOP, Receptors, OP3, Mu, Opioid, 0591, Tocris Bioscience

3 Citations for Naloxonazine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Naloxonazine dihydrochloride include:

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641

Lee et al (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. J Biomed Sci 2012 941685 PMID: 22645476

Yi et al (2015) Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. BMC Cell Biol 22 49 PMID: 26150021


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