Potent opioid antagonist, selective for μ1 receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 25 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 723.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.38 mL||6.91 mL||13.82 mL|
|5 mM||0.28 mL||1.38 mL||2.76 mL|
|10 mM||0.14 mL||0.69 mL||1.38 mL|
|50 mM||0.03 mL||0.14 mL||0.28 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Paul et al (1988) Differential blockade by naloxonazine of two μ opiate actions: analgesic and inhibition of gastrointestinal transit. Eur.J.Pharmacol. 149 403 PMID: 2842168
If you know of a relevant reference for Naloxonazine dihydrochloride, please let us know.
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Keywords: Selective antagonists μ-opioid mu-opioid μ1-opioid mu1-opioid MOP Receptors OP3 Mu Opioid Receptors
3 Citations for Naloxonazine dihydrochloride
Citations are publications that use Tocris products. Selected citations for Naloxonazine dihydrochloride include:
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
Yi et al (2015) Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. BMC Cell Biol 22 49 PMID: 26150021
Lee et al (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. J Biomed Sci 2012 941685 PMID: 22645476
Do you know of a great paper that uses Naloxonazine dihydrochloride from Tocris? If so please let us know.
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