Naloxonazine dihydrochloride

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Cat.No. 0591 - Naloxonazine dihydrochloride | C38H42N4O6.2HCl | CAS No. 880759-65-9
Description: Selective μ1 antagonist
Chemical Name: Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene] hydrazine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Potent opioid antagonist, selective for μ1 receptors.

Technical Data

M. Wt 723.69
Formula C38H42N4O6.2HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 880759-65-9
PubChem ID 90479735
InChI Key VIAIHLLKDJKEKM-JNHLASQBSA-N
Smiles OC(C(N(CC=C)CC%10)C6)7C2%10C1=C6C=CC(O)=C1OC2/C(CC7)=N/N=C3CCC8(O)C49C/3OC5=C(O)C=CC(CC8N(CC=C)CC9)=C45.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 25 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 723.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.38 mL 6.91 mL 13.82 mL
5 mM 0.28 mL 1.38 mL 2.76 mL
10 mM 0.14 mL 0.69 mL 1.38 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Paul et al (1988) Differential blockade by naloxonazine of two μ opiate actions: analgesic and inhibition of gastrointestinal transit. Eur.J.Pharmacol. 149 403 PMID: 2842168


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View all μ Opioid Receptor Antagonists

Keywords: Naloxonazine dihydrochloride, supplier, Selective, antagonists, μ-opioid, mu-opioid, μ1-opioid, mu1-opioid, MOP, Receptors, OP3, Mu, Opioid, Receptors, Tocris Bioscience

3 Citations for Naloxonazine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Naloxonazine dihydrochloride include:

Lee et al (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. J Biomed Sci 2012 941685 PMID: 22645476

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641

Yi et al (2015) Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. BMC Cell Biol 22 49 PMID: 26150021


Do you know of a great paper that uses Naloxonazine dihydrochloride from Tocris? If so please let us know.

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