Naftopidil hydrochloride

Pricing Availability   Qty
Description: α1 antagonist
Chemical Name: 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Naftopidil hydrochloride

An α1-adrenoceptor antagonist with only weak antagonism at post-junctional α2 receptors; a potent, persistent antihypertensive and vasodilator.

Technical Data for Naftopidil hydrochloride

M. Wt 428.96
Formula C24H28N2O3.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1164469-60-6
PubChem ID 6603044

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Naftopidil hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.9 100

Preparing Stock Solutions for Naftopidil hydrochloride

The following data is based on the product molecular weight 428.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.66 mL 23.31 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Naftopidil hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for Naftopidil hydrochloride

References are publications that support the biological activity of the product.

Borbe and Peter (1990) Alpha-1-adrenoceptor-binding material in rat plasma following single oral administration of naftopidil. Arzneimittelforschung 40 253 PMID: 1971750

Muramatsu et al (1991) Pharmacological profile of the novel alpha-adrenoceptor antagonist KT-611 (naftopidil). Jpn.J.Pharmacol. 55 391 PMID: 1677438

If you know of a relevant reference for Naftopidil hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Adrenergic α1 Receptor Antagonists

Keywords: Naftopidil hydrochloride, Naftopidil hydrochloride supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, antagonists, α1-adrenergic, alpha1-adrenergic, a1-adrenergic, Receptors, Adrenergic, Alpha-1, 0597, Tocris Bioscience

Citations for Naftopidil hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Naftopidil hydrochloride. Do you know of a great paper that uses Naftopidil hydrochloride from Tocris? Please let us know.

Reviews for Naftopidil hydrochloride

There are currently no reviews for this product. Be the first to review Naftopidil hydrochloride and earn rewards!

Have you used Naftopidil hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.