Naftopidil hydrochloride

Discontinued Product

Naftopidil hydrochloride (Cat. No. 0597) has been withdrawn from sale for commercial reasons.
Description: α1 antagonist
Chemical Name: 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for Naftopidil hydrochloride

An α1-adrenoceptor antagonist with only weak antagonism at post-junctional α2 receptors; a potent, persistent antihypertensive and vasodilator.

Technical Data for Naftopidil hydrochloride

M. Wt 428.96
Formula C24H28N2O3.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1164469-60-6
PubChem ID 6603044
InChI Key VQAAEWMEVIOHTJ-UHFFFAOYSA-N
Smiles Cl.COC1=C(C=CC=C1)N1CCN(CC(O)COC2=C3C=CC=CC3=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Naftopidil hydrochloride

Certificate of Analysis / Product Datasheet
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References for Naftopidil hydrochloride

References are publications that support the biological activity of the product.

Borbe and Peter (1990) Alpha-1-adrenoceptor-binding material in rat plasma following single oral administration of naftopidil. Arzneimittelforschung 40 253 PMID: 1971750

Muramatsu et al (1991) Pharmacological profile of the novel alpha-adrenoceptor antagonist KT-611 (naftopidil). Jpn.J.Pharmacol. 55 391 PMID: 1677438

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Citations for Naftopidil hydrochloride

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Currently there are no citations for Naftopidil hydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.