NAB 2

Pricing Availability Delivery Time Qty
Cat.No. 5131 - NAB 2 | C23H20ClN3O | CAS No. 1504588-00-4
Description: Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport
Chemical Name: N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Protects against α-synuclein toxicity. Reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. Promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Compound Libraries

NAB 2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 389.88
Formula C23H20ClN3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1504588-00-4
PubChem ID 82017756
InChI Key CZSLEMCYYGEGKP-UHFFFAOYSA-N
Smiles O=C(NCC4=C(Cl)C=CC=C4)C1=CC=C2C(N=CN2C3=CC(C)=CC=C3C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 38.99 100
DMSO 38.99 100

Preparing Stock Solutions

The following data is based on the product molecular weight 389.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.82 mL 25.65 mL
5 mM 0.51 mL 2.56 mL 5.13 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Tardiff et al (2013) Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 342 979 PMID: 24158909

Chung et al (2013) Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 342 983 PMID: 24158904


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Keywords: NAB 2, supplier, NAB2, α, alpha-synuclein, a-synuclein, toxicity, Parkinsons, disease, parkinson's, NEDD4, rsp5, Ubiquitin, E3, Ligases, Ubiquitin, E3, Ligases, Tocris Bioscience

1 Citation for NAB 2

Citations are publications that use Tocris products. Selected citations for NAB 2 include:

Caires-Júnior (2018) Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun 9 475 PMID: 29396410


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Literature in this Area

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