Protects against α-synuclein toxicity. Reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. Promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.
Sold under license from Whitehead Institute for Biomedical Research.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 389.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.56 mL||12.82 mL||25.65 mL|
|5 mM||0.51 mL||2.56 mL||5.13 mL|
|10 mM||0.26 mL||1.28 mL||2.56 mL|
|50 mM||0.05 mL||0.26 mL||0.51 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Tardiff et al (2013) Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 342 979 PMID: 24158909
Chung et al (2013) Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 342 983 PMID: 24158904
If you know of a relevant reference for NAB 2, please let us know.
Keywords: NAB2 α alpha-synuclein a-synuclein toxicity Parkinsons disease parkinson's NEDD4 rsp5 Ubiquitin E3 Ligases
Citations for NAB 2
Citations are publications that use Tocris products.
Currently there are no citations for NAB 2. Do you know of a great paper that uses NAB 2 from Tocris? If so please let us know.
Literature in this Area
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.