NAB 2

Pricing Availability Delivery Time Qty
Cat.No. 5131 - NAB 2 | C23H20ClN3O | CAS No. 1504588-00-4
Description: Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport
Chemical Name: N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Protects against α-synuclein toxicity. Reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. Promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Compound Libraries

NAB 2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 389.88
Formula C23H20ClN3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1504588-00-4
PubChem ID 82017756
InChI Key CZSLEMCYYGEGKP-UHFFFAOYSA-N
Smiles O=C(NCC4=C(Cl)C=CC=C4)C1=CC=C2C(N=CN2C3=CC(C)=CC=C3C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.99 100
ethanol 38.99 100

Preparing Stock Solutions

The following data is based on the product molecular weight 389.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.82 mL 25.65 mL
5 mM 0.51 mL 2.56 mL 5.13 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Tardiff et al (2013) Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 342 979 PMID: 24158909

Chung et al (2013) Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 342 983 PMID: 24158904


If you know of a relevant reference for NAB 2, please let us know.

Keywords: NAB2 α alpha-synuclein a-synuclein toxicity Parkinsons disease parkinson's NEDD4 rsp5 Ubiquitin E3 Ligases

Citations for NAB 2

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Literature in this Area

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for NAB 2

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