Home / Pharmacology / Enzymes / Ligases / Ubiquitin E3 Ligases / NAB 2

NAB 2

Cat. No. 5131 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport
Chemical Name: N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NAB 2

NAB 2 protects against α-synuclein toxicity. NAB 2 reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. NAB 2 promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Technical Data for NAB 2

M. Wt 389.88
Formula C23H20ClN3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1504588-00-4
PubChem ID 82017756
InChI Key CZSLEMCYYGEGKP-UHFFFAOYSA-N
Smiles O=C(NCC4=C(Cl)C=CC=C4)C1=CC=C2C(N=CN2C3=CC(C)=CC=C3C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NAB 2

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.99 100
ethanol 38.99 100

Preparing Stock Solutions for NAB 2

The following data is based on the product molecular weight 389.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.82 mL 25.65 mL
5 mM 0.51 mL 2.56 mL 5.13 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets for NAB 2

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for NAB 2

References are publications that support the biological activity of the product.

Tardiff et al (2013) Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 342 979 PMID: 24158909

Chung et al (2013) Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 342 983 PMID: 24158904

Hatstat et al (2021) Characterization of small-molecule-induced changes in Parkinson's-related trafficking via the Nedd4 ubiquitin signaling cascade. Cell Chem.Biol. 28 14 PMID: 33176158

If you know of a relevant reference for NAB 2, please let us know.

View Related Products by Target

Keywords: NAB 2, NAB 2 supplier, NAB2, α, alpha-synuclein, a-synuclein, toxicity, Parkinsons, disease, parkinson's, NEDD4, rsp5, Ubiquitin, E3, Ligases, 5131, Tocris Bioscience

1 Citation for NAB 2

Citations are publications that use Tocris products. Selected citations for NAB 2 include:

Caires-Júnior (2018) Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat Commun 9 475 PMID: 29396410

Do you know of a great paper that uses NAB 2 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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