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Description: High affinity A1 receptor agonist
Chemical Name: N-Cyclohexyladenosine
Purity: ≥98% (HPLC)

Biological Activity for N6-Cyclohexyladenosine

N6-Cyclohexyladenosine is a high affinity adenosine A1 receptor agonist (Kd values are 0.7 and 6 nM for bovine and guinea pig brain membranes, respectively). Reduces light-induced circadian phase delays. Exhibits protective effect in lysolecithin-induced demyelination model. When administered prior to ischemia, improves functional recovery of heart in a mouse model of ischemia-reperfusion injury. Induces hypothermia following icv administration in mice.

Compound Libraries for N6-Cyclohexyladenosine

N6-Cyclohexyladenosine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for N6-Cyclohexyladenosine

M. Wt 349.38
Formula C16H23N5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 36396-99-3
PubChem ID 9841284
Smiles OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(NC3CCCCC3)N=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for N6-Cyclohexyladenosine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.94 100
ethanol 6.99 20

Preparing Stock Solutions for N6-Cyclohexyladenosine

The following data is based on the product molecular weight 349.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.31 mL 28.62 mL
5 mM 0.57 mL 2.86 mL 5.72 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets for N6-Cyclohexyladenosine

Certificate of Analysis / Product Datasheet
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References for N6-Cyclohexyladenosine

References are publications that support the biological activity of the product.

Bruns et al (1980) Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine. Proc.Natl.Acad.Sci.U.S.A. 77 5547 PMID: 6254090

Sigworth and Rea et al (2003) Adenosine A1 receptors regulate the response of the mouse circadian clock to light. Brain Res. 960 246 PMID: 12505678

Asghari et al (2013) Adenosine A1 receptor agonist, N6-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies. J.Neurol.Sci. 325 22 PMID: 23260322

Shao et al (2017) Adenosine A1 receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts. PLoS One 12 e0177315 PMID: 28493997

Futatsuki et al (2018) Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia. Sci.Rep. 8 2717 PMID: 29426934

If you know of a relevant reference for N6-Cyclohexyladenosine, please let us know.

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Citations for N6-Cyclohexyladenosine

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