N106

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Cat.No. 5681 - N106 | C17H14N4O3S | CAS No. 862974-25-2
Description: Activator of SUMO-activating enzyme, E1 ligase
Chemical Name: 4-Methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl-2-benzothiazolamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Improves ventricular function in a mouse model of heart disease.

Technical Data

M. Wt 354.38
Formula C17H14N4O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 862974-25-2
PubChem ID 3236395
InChI Key FBCSWQRNKAYAGY-UHFFFAOYSA-N
Smiles COC1=C(N=C(NC2=NN=C(C3=CC=C(OC)C=C3)O2)S4)C4=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.09 20

Preparing Stock Solutions

The following data is based on the product molecular weight 354.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.22 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Kho et al (2015) Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat.Commun. 6 7229 PMID: 26068603


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Keywords: N106, supplier, SUMO-activating, enzymes, E1, ligases, SERCA2a, SUMOylation, heart, diseases, activators, Other, Ligases, Other, Ligases, Tocris Bioscience

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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