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Activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Improves ventricular function in a mouse model of heart disease.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||7.09||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 354.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||14.11 mL||70.55 mL||141.09 mL|
|1 mM||2.82 mL||14.11 mL||28.22 mL|
|2 mM||1.41 mL||7.05 mL||14.11 mL|
|10 mM||0.28 mL||1.41 mL||2.82 mL|
References are publications that support the biological activity of the product.
Kho et al (2015) Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat.Commun. 6 7229 PMID: 26068603
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Keywords: N106, N106 supplier, SUMO-activating, enzymes, E1, ligases, SERCA2a, SUMOylation, heart, diseases, activators, Other, Ligases, 5681, Tocris Bioscience
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