Pricing Availability   Qty
Description: Activator of SUMO-activating enzyme, E1 ligase
Chemical Name: 4-Methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl-2-benzothiazolamine
Purity: ≥98% (HPLC)

Biological Activity for N106

N106 is an activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Improves ventricular function in a mouse model of heart disease.

Compound Libraries for N106

N106 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for N106

M. Wt 354.38
Formula C17H14N4O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 862974-25-2
PubChem ID 3236395
Smiles COC1=C(N=C(NC2=NN=C(C3=CC=C(OC)C=C3)O2)S4)C4=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for N106

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.09 20 with gentle warming

Preparing Stock Solutions for N106

The following data is based on the product molecular weight 354.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.11 mL 70.55 mL 141.09 mL
1 mM 2.82 mL 14.11 mL 28.22 mL
2 mM 1.41 mL 7.05 mL 14.11 mL
10 mM 0.28 mL 1.41 mL 2.82 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for N106

References are publications that support the biological activity of the product.

Kho et al (2015) Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat.Commun. 6 7229 PMID: 26068603

If you know of a relevant reference for N106, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Ligase Activators

Keywords: N106, N106 supplier, SUMO-activating, enzymes, E1, ligases, SERCA2a, SUMOylation, heart, diseases, activators, Other, Ligases, 5681, Tocris Bioscience

Citations for N106

Citations are publications that use Tocris products.

Currently there are no citations for N106. Do you know of a great paper that uses N106 from Tocris? Please let us know.

Reviews for N106

There are currently no reviews for this product. Be the first to review N106 and earn rewards!

Have you used N106?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review