N-Nonyldeoxynojirimycin

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Cat.No. 3691 - N-Nonyldeoxynojirimycin | C15H31NO4 | CAS No. 81117-35-3
Description: Glucosidase inhibitor
Alternative Names: NN-DNJ
Chemical Name: (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol
Datasheet
Citations
Literature

Biological Activity

Glucosidase inhibitor (IC50 values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.

Technical Data

M. Wt 289.41
Formula C15H31NO4
Storage Store at -20°C
CAS Number 81117-35-3
PubChem ID 501640
InChI Key FTSCEGKYKXESFF-LXTVHRRPSA-N
Smiles O[C@H]1[C@H](O)[C@@H](CO)N(CCCCCCCCC)C[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.94 100
ethanol 28.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 289.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.46 mL 17.28 mL 34.55 mL
5 mM 0.69 mL 3.46 mL 6.91 mL
10 mM 0.35 mL 1.73 mL 3.46 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Andersson et al (2004) Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem.Pharmacol. 67 697 PMID: 14757169

Mellor et al (2004) Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 381 867 PMID: 15128289

Sawkar et al (2002) Chemical chaperones increase the cellular activity of N307S β-glucosidase: a therapeutic strategy for Gaucher disease. Proc.Natl.Acad.Sci.USA 99 15428 PMID:


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View all Glycosylase Inhibitors

Keywords: Glucosidase inhibitors inhibits acid α-glucosidase alpha-glucosidase GAA α-1 6-glucosidase alpha-1 6-glucosidaset a-glucosidase glycosylases chemical chaperone NNDNJ NN-DNJ Glycosylases

Citations for N-Nonyldeoxynojirimycin

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