N-Nonyldeoxynojirimycin
Biological Activity
Glucosidase inhibitor (IC50 values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.
Technical Data
| M. Wt | 289.41 |
| Formula | C15H31NO4 |
| Storage | Store at -20°C |
| CAS Number | 81117-35-3 |
| PubChem ID | 501640 |
| InChI Key | FTSCEGKYKXESFF-LXTVHRRPSA-N |
| Smiles | O[C@H]1[C@H](O)[C@@H](CO)N(CCCCCCCCC)C[C@@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.94 | 100 | |
| ethanol | 28.94 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 289.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.46 mL | 17.28 mL | 34.55 mL |
| 5 mM | 0.69 mL | 3.46 mL | 6.91 mL |
| 10 mM | 0.35 mL | 1.73 mL | 3.46 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
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References
References are publications that support the products' biological activity.
Andersson et al (2004) Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem.Pharmacol. 67 697 PMID: 14757169
Mellor et al (2004) Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 381 867 PMID: 15128289
Sawkar et al (2002) Chemical chaperones increase the cellular activity of N307S β-glucosidase: a therapeutic strategy for Gaucher disease. Proc.Natl.Acad.Sci.USA 99 15428 PMID:
If you know of a relevant reference for N-Nonyldeoxynojirimycin, please let us know.
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Keywords: Glucosidase inhibitors inhibits acid α-glucosidase alpha-glucosidase GAA α-1 6-glucosidase alpha-1 6-glucosidaset a-glucosidase glycosylases chemical chaperone NNDNJ NN-DNJ Glycosylases
Citations for N-Nonyldeoxynojirimycin
Citations are publications that use Tocris products.
Currently there are no citations for N-Nonyldeoxynojirimycin. Do you know of a great paper that uses N-Nonyldeoxynojirimycin from Tocris? If so please let us know.
Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Apoptosis
- Cell Metabolism
- Epigenetics
- Fluorescent Imaging
- Signal Transduction
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