Glucosidase inhibitor (IC50 values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 289.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.46 mL||17.28 mL||34.55 mL|
|5 mM||0.69 mL||3.46 mL||6.91 mL|
|10 mM||0.35 mL||1.73 mL||3.46 mL|
|50 mM||0.07 mL||0.35 mL||0.69 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Andersson et al (2004) Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem.Pharmacol. 67 697 PMID: 14757169
Mellor et al (2004) Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 381 867 PMID: 15128289
If you know of a relevant reference for N-Nonyldeoxynojirimycin, please let us know.
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Keywords: Glucosidase inhibitors inhibits acid α-glucosidase alpha-glucosidase GAA α-1 6-glucosidase alpha-1 6-glucosidaset a-glucosidase glycosylases chemical chaperone NNDNJ NN-DNJ Glycosylases
Citations for N-Nonyldeoxynojirimycin
Citations are publications that use Tocris products.
Currently there are no citations for N-Nonyldeoxynojirimycin. Do you know of a great paper that uses N-Nonyldeoxynojirimycin from Tocris? If so please let us know.
Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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