N-Nonyldeoxynojirimycin
Biological Activity
Glucosidase inhibitor (IC50 values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.
Technical Data
| M. Wt | 289.41 |
| Formula | C15H31NO4 |
| Storage | Store at -20°C |
| CAS Number | 81117-35-3 |
| PubChem ID | 501640 |
| InChI Key | FTSCEGKYKXESFF-LXTVHRRPSA-N |
| Smiles | O[C@H]1[C@H](O)[C@@H](CO)N(CCCCCCCCC)C[C@@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.94 | 100 | |
| ethanol | 28.94 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 289.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.46 mL | 17.28 mL | 34.55 mL |
| 5 mM | 0.69 mL | 3.46 mL | 6.91 mL |
| 10 mM | 0.35 mL | 1.73 mL | 3.46 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
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References
References are publications that support the biological activity of the product.
Andersson et al (2004) Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem.Pharmacol. 67 697 PMID: 14757169
Mellor et al (2004) Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 381 867 PMID: 15128289
Sawkar et al (2002) Chemical chaperones increase the cellular activity of N307S β-glucosidase: a therapeutic strategy for Gaucher disease. Proc.Natl.Acad.Sci.USA 99 15428
If you know of a relevant reference for N-Nonyldeoxynojirimycin, please let us know.
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Keywords: N-Nonyldeoxynojirimycin, N-Nonyldeoxynojirimycin supplier, Glucosidase, inhibitors, inhibits, acid, α-glucosidase, alpha-glucosidase, GAA, α-1, 6-glucosidase, alpha-1, 6-glucosidaset, a-glucosidase, glycosylases, chemical, chaperone, NNDNJ, NN-DNJ, Glycosylases, 3691, Tocris Bioscience
Citations for N-Nonyldeoxynojirimycin
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