N-ArachidonylGABA

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Cat.No. 1814 - N-ArachidonylGABA | C24H39NO3 | CAS No. 128201-89-8
Description: Inhibits pain in vivo
Alternative Names: NAGABA
Chemical Name: 4-[[(5Z,8Z,11Z,14Z)-1-Oxo-5,8,11,14-eicosatetraenyl]amino]butanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Arachidonyl amino acid; first isolated from bovine brain. Inhibits pain in vivo.

Technical Data

M. Wt 389.58
Formula C24H39NO3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 128201-89-8
PubChem ID 16759310
InChI Key JKUDIEXTAYKJNX-DOFZRALJSA-N
Smiles CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 389.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.83 mL 25.67 mL
5 mM 0.51 mL 2.57 mL 5.13 mL
10 mM 0.26 mL 1.28 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

El Fangour et al (2003) Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues. Bioorg.Med.Chem.Lett. 13 1977 PMID: 12781177

Huang et al (2001) Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J.Biol.Chem. 276 42639 PMID: 11518719


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Keywords: N-ArachidonylGABA, supplier, inhibitors, inhibits, pain, vivo, cannabinoids, Receptors, GABAB, GABA, GABAA, GABAC, NAGABA, Miscellaneous, GABA, Other, Cannabinoids, GABAB, Receptors, Miscellaneous, GABA, Tocris Bioscience

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Literature in this Area

GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.