Discontinued Product

N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide (Cat. No. 0722) has been withdrawn from sale for commercial reasons.
Description: Nitroxyl precursor

Biological Activity

A pro-drug of the potent vasorelaxant nitroxyl, H-N=O, which it slowly releases in neutral solution. HNO eventually dimerizes and dehydrates to N2O, without producing NO. Also a powerful inhibitor of aldehyde dehydrogenase.

Technical Data

M. Wt 291.71
Formula C10H10ClNO5S
Storage Desiccate at +4°C
CAS Number 142867-52-5
PubChem ID 688598
Smiles ClC1=CC=C(S(N(C(C)=O)OC(C)=O)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.


References are publications that support the biological activity of the product.

Fukuto et al (1992) N,O-Diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties. Biochem.Biophys.Res.Commun. 187 1367 PMID: 1417812

Lee et al (1992) Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase. J.Med.Chem. 35 3648 PMID: 1433175

Keywords: N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide, N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide supplier, Nitroxyl, precursor, ROS, Donors, NO, Precursors, Nitric, Oxide, Signaling, Signalling, /, 0722, Tocris Bioscience

Citations for N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide

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Currently there are no citations for N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide.

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