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Cat.No. 0722 - N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide | C10H10ClNO5S | CAS No. 142867-52-5
Description: Nitroxyl precursor

Biological Activity

A pro-drug of the potent vasorelaxant nitroxyl, H-N=O, which it slowly releases in neutral solution. HNO eventually dimerizes and dehydrates to N2O, without producing NO. Also a powerful inhibitor of aldehyde dehydrogenase.

Technical Data

M. Wt 291.71
Formula C10H10ClNO5S
Storage Desiccate at +4°C
CAS Number 142867-52-5
PubChem ID 688598
Smiles ClC1=CC=C(S(N(C(C)=O)OC(C)=O)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.17 100

Preparing Stock Solutions

The following data is based on the product molecular weight 291.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.14 mL 34.28 mL
5 mM 0.69 mL 3.43 mL 6.86 mL
10 mM 0.34 mL 1.71 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Fukuto et al (1992) N,O-Diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties. Biochem.Biophys.Res.Commun. 187 1367 PMID: 1417812

Lee et al (1992) Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase. J.Med.Chem. 35 3648 PMID: 1433175

If you know of a relevant reference for N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide, please let us know.

Keywords: N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide, supplier, Nitroxyl, precursor, ROS, Donors, NO, Precursors, Nitric, Oxide, Signaling, Signalling, NO, Donors, /, Precursors, ROS, Donors, NO, Donors, /, Precursors, Tocris Bioscience

Citations for N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide

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