MSG 606

Discontinued Product

MSG 606 (Cat. No. 5954) has been withdrawn from sale for commercial reasons.
Description: Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for MSG 606

MSG 606 is a potent human MC1 receptor antagonist (IC50 = 17 nM). Also partial agonist at human MC3 and MC5 receptors (EC50 values are 59 and 1300 nM, respectively). Exhibits binding affinity for A375 melanoma cells in vitro. Reverses morphine-induced hyperalgesia in female mice, with no effect in male mice. γMSH analog.

Technical Data for MSG 606

M. Wt 1347.51
Formula C62H82N20O13S

(Modifications: X = Butanoic acid, Phe-4 = D-Phe, Trp-6 = D-Trp, Gly-11 = C-terminal amide, Carba sulfide bridge: X-1 - Cys-7)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1416983-77-1
PubChem ID 122177131
Smiles NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CSCCCC(=O)NCC(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for MSG 606

Certificate of Analysis / Product Datasheet
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References for MSG 606

References are publications that support the biological activity of the product.

Cai et al (2013) An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells. Biochemistry 52 752 PMID: 23276279

Juni et al (2010) Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. Anesthesiology 112 181 PMID: 19996949

Arout et al (2015) Spinal and supraspinal N-methyl-D-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia. Physiol.Behav. 147 364 PMID: 25982086

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Keywords: MSG 606, MSG 606 supplier, MSG606, potent, MC1, receptors, melanocortin, antagonists, partial, agonists, MC3, MC5, hyperalgesia, Melanocortin, Receptors, 5954, Tocris Bioscience

Citations for MSG 606

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Currently there are no citations for MSG 606.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.