MSG 606

Pricing Availability Delivery Time Qty
Cat.No. 5954 - MSG 606 | Butyryl-Gly-His-D-Phe-Arg-D-Trp-Cys-Asp-Arg-Phe-Gly-NH2 | CAS No. 1416983-77-1
Description: Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent human MC1 receptor antagonist (IC50 = 17 nM). Also partial agonist at human MC3 and MC5 receptors (EC50 values are 59 and 1300 nM, respectively). Exhibits binding affinity for A375 melanoma cells in vitro. Reverses morphine-induced hyperalgesia in female mice, with no effect in male mice. γMSH analog.

Technical Data

M. Wt 1347.51
Formula C62H82N20O13S
Sequence XGHFRWCDRFG

(Modifications: X = Butanoic acid, Gly-11 = C-terminal amide, Phe-4 = D-Phe, Trp-6 = D-Trp, carba sulfide bridge between X-1 - Cys-7)

Storage Store at -20°C
CAS Number 1416983-77-1
PubChem ID 122177131
InChI Key QJBNFEXQHBDMQM-VTWSTLNFSA-N
Smiles NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CSCCCC(=O)NCC(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1347.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.74 mL 3.71 mL 7.42 mL
5 mM 0.15 mL 0.74 mL 1.48 mL
10 mM 0.07 mL 0.37 mL 0.74 mL
50 mM 0.01 mL 0.07 mL 0.15 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cai et al (2013) An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells. Biochemistry 52 752 PMID: 23276279

Juni et al (2010) Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. Anesthesiology 112 181 PMID: 19996949

Arout et al (2015) Spinal and supraspinal N-methyl-D-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia. Physiol.Behav. 147 364 PMID: 25982086


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Keywords: MSG 606, supplier, MSG606, potent, MC1, receptors, melanocortin, antagonists, partial, agonists, MC3, MC5, hyperalgesia, Melanocortin, Receptors, Melanocortin, Receptors, Tocris Bioscience

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