MS 245 oxalate

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Cat.No. 4208 - MS 245 oxalate | C19H22N2O3S.C2H2O4 | CAS No. 275363-58-1
Description: High affinity 5-HT6 antagonist
Chemical Name: 5-Methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine oxalate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity 5-HT6 antagonist (Ki = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice.

Technical Data

M. Wt 448.49
Formula C19H22N2O3S.C2H2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 275363-58-1
PubChem ID 6918541
InChI Key BLSWAEGCRSFTJG-UHFFFAOYSA-N
Smiles O=S(N2C1=CC=C(OC)C=C1C(CCN(C)C)=C2)(C3=CC=CC=C3)=O.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.42 50

Preparing Stock Solutions

The following data is based on the product molecular weight 448.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164

Dukat et al (2008) Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. J.Med.Chem. 51 603 PMID: 18201064

Nirogi et al (2010) Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands. ACS Med.Chem.Lett. 1 340 PMID:

Young et al (2006) Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (-)nicotine. Pharmacol.Biochem.Behav. 85 170 PMID: 16950502


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Keywords: MS245 5ht6 serotonin serotonergic antagonists 5-HT6 Receptors

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