MS 245 oxalate

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Cat.No. 4208 - MS 245 oxalate | C19H22N2O3S.C2H2O4 | CAS No. 275363-58-1
Description: High affinity 5-HT6 antagonist
Chemical Name: 5-Methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine oxalate
Purity: ≥99% (HPLC)
Literature (4)

Biological Activity

High affinity 5-HT6 antagonist (Ki = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice.

Technical Data

M. Wt 448.49
Formula C19H22N2O3S.C2H2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 275363-58-1
PubChem ID 6918541
Smiles O=S(N2C1=CC=C(OC)C=C1C(CCN(C)C)=C2)(C3=CC=CC=C3)=O.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.42 50

Preparing Stock Solutions

The following data is based on the product molecular weight 448.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.46 mL 22.3 mL 44.59 mL
2.5 mM 0.89 mL 4.46 mL 8.92 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
25 mM 0.09 mL 0.45 mL 0.89 mL

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References are publications that support the biological activity of the product.

Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164

Dukat et al (2008) Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. J.Med.Chem. 51 603 PMID: 18201064

Nirogi et al (2010) Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands. ACS Med.Chem.Lett. 1 340

Young et al (2006) Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (-)nicotine. Pharmacol.Biochem.Behav. 85 170 PMID: 16950502

If you know of a relevant reference for MS 245 oxalate, please let us know.

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