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Submit ReviewMS 245 oxalate
Description: High affinity 5-HT6 antagonist
Chemical Name: 5-Methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine oxalate
Purity: ≥99% (HPLC)
Biological Activity for MS 245 oxalate
MS 245 oxalate is a high affinity 5-HT6 antagonist (Ki = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice.
Technical Data for MS 245 oxalate
| M. Wt | 448.49 |
| Formula | C19H22N2O3S.C2H2O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 275363-58-1 |
| PubChem ID | 6918541 |
| InChI Key | BLSWAEGCRSFTJG-UHFFFAOYSA-N |
| Smiles | O=S(N2C1=CC=C(OC)C=C1C(CCN(C)C)=C2)(C3=CC=CC=C3)=O.OC(C(O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MS 245 oxalate
References for MS 245 oxalate
References are publications that support the biological activity of the product.
Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164
Dukat et al (2008) Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. J.Med.Chem. 51 603 PMID: 18201064
Nirogi et al (2010) Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands. ACS Med.Chem.Lett. 1 340
Young et al (2006) Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (-)nicotine. Pharmacol.Biochem.Behav. 85 170 PMID: 16950502
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Keywords: MS 245 oxalate, MS 245 oxalate supplier, MS245, 5ht6, serotonin, serotonergic, antagonists, 5-HT6, Receptors, 4208, Tocris Bioscience
Citations for MS 245 oxalate
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
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