Mpro 61

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Description: Potent non-covalent inhibitor of SARS-CoV-2 main protease
Chemical Name: 5-[5-[3-Chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl]-6-oxo[1(6H),3'-bipyridin]-3-yl]-1-methyl-2,4(1H,3H)-pyrimidinedione
Purity: ≥95% (HPLC)

Biological Activity for Mpro 61

Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease (IC50 = 44 nM, EC50 = 0.175 μM in the replicon assay and EC50 = 0.08 μM in the infectious SARS-CoV-2 assay); it is cell permable and exhibits no apparent cytotoxicity.

Licensing Information

Sold under license from Yale University. U.S. patent application number 63/135,062.

Technical Data for Mpro 61

M. Wt 565.38
Formula C28H19Cl2FN4O4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2679814-93-6
PubChem ID 156587560
Smiles CN1C=C(C2=CN(C3=CN=CC=C3)C(C(C4=CC(OCC5=C(C=CC=C5)Cl)=C(C(Cl)=C4)F)=C2)=O)C(NC1=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mpro 61

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.31 20

Preparing Stock Solutions for Mpro 61

The following data is based on the product molecular weight 565.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.84 mL 44.22 mL 88.44 mL
1 mM 1.77 mL 8.84 mL 17.69 mL
2 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.18 mL 0.88 mL 1.77 mL

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Product Datasheets for Mpro 61

Certificate of Analysis / Product Datasheet
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References for Mpro 61

References are publications that support the biological activity of the product.

Zhang et al (2021) Optimization of triarylpyridinone inhibitors of the main protease of SARS-CoV-2 to low-nanomolar antiviral potency. ACS Med.Chem.Lett. 12 1325 PMID: 34408808

If you know of a relevant reference for Mpro 61, please let us know.

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Citations for Mpro 61

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