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Biological Activity for Mpro 61
Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease (IC50 = 44 nM, EC50 = 0.175 μM in the replicon assay and EC50 = 0.08 μM in the infectious SARS-CoV-2 assay); it is cell permable and exhibits no apparent cytotoxicity.
Sold under license from Yale University. U.S. patent application number 63/135,062.
Technical Data for Mpro 61
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Mpro 61
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Mpro 61
The following data is based on the product molecular weight 565.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||8.84 mL||44.22 mL||88.44 mL|
|1 mM||1.77 mL||8.84 mL||17.69 mL|
|2 mM||0.88 mL||4.42 mL||8.84 mL|
|10 mM||0.18 mL||0.88 mL||1.77 mL|
References for Mpro 61
References are publications that support the biological activity of the product.
Zhang et al (2021) Optimization of triarylpyridinone inhibitors of the main protease of SARS-CoV-2 to low-nanomolar antiviral potency. ACS Med.Chem.Lett. 12 1325 PMID: 34408808
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