MPro 13b

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Cat.No. 7228 - MPro 13b | C31H39N5O7 | CAS No. 2412965-59-2
Description: Coronavirus Mpro inhibitor
Chemical Name: tert-Butyl (1-((S)-1-(((S)-4-(benzylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-3-cyclopropyl-1-oxopropan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate
Purity: ≥97% (HPLC)
Literature (1)

Biological Activity for MPro 13b

MPro 13b is a coronavirus Mpro inhibitor (IC50 values are 0.58, 0.9 and 0.67 μM for recombinant Mpro from MERS-CoV, SARS-CoV and SARS-CoV-2, respectively). MPro 13b inhibits SARS-CoV-2 infection of human Calu3 cells (IC50 = 4-5 μM).

Please note, unpublished data suggest MPro 13b is 2-fold more potent than published data.

Licensing Information

Sold under license from the University of Lübeck

Technical Data for MPro 13b

M. Wt 593.68
Formula C31H39N5O7
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 2412965-59-2
PubChem ID 146026181
Smiles CC(C)(OC(NC1=CC=CN(C1=O)[C@H](C(N[C@H](C(C(NCC2=CC=CC=C2)=O)=O)C[C@@H]3CCNC3=O)=O)CC4CC4)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MPro 13b

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 59.37 100

Preparing Stock Solutions for MPro 13b

The following data is based on the product molecular weight 593.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.68 mL 8.42 mL 16.84 mL
5 mM 0.34 mL 1.68 mL 3.37 mL
10 mM 0.17 mL 0.84 mL 1.68 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets for MPro 13b

Certificate of Analysis / Product Datasheet
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References for MPro 13b

References are publications that support the biological activity of the product.

Zhang et al (2020) Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Science. 368 409 PMID: 32198291

If you know of a relevant reference for MPro 13b, please let us know.

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Citations for MPro 13b

Citations are publications that use Tocris products.

Currently there are no citations for MPro 13b. Do you know of a great paper that uses MPro 13b from Tocris? Please let us know.

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Literature in this Area

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