MPro 13b

Pricing Availability   Qty
Cat.No. 7228 - MPro 13b | C31H39N5O7 | CAS No. 2412965-59-2
Description: Coronavirus Mpro inhibitor
Chemical Name: tert-Butyl (1-((S)-1-(((S)-4-(benzylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-3-cyclopropyl-1-oxopropan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for MPro 13b

MPro 13b is a coronavirus Mpro inhibitor (IC50 values are 0.58, 0.9 and 0.67 μM for recombinant Mpro from MERS-CoV, SARS-CoV and SARS-CoV-2, respectively). MPro 13b inhibits SARS-CoV-2 infection of human Calu3 cells (IC50 = 4-5 μM).

Please note, unpublished data suggest MPro 13b is 2-fold more potent than published data.

Licensing Information

Sold under license from the University of Lübeck

Technical Data for MPro 13b

M. Wt 593.68
Formula C31H39N5O7
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 2412965-59-2
PubChem ID 146026181
InChI Key NLVRHQFXQFSBQK-XWGVYQGASA-N
Smiles CC(C)(OC(NC1=CC=CN(C1=O)[C@H](C(N[C@H](C(C(NCC2=CC=CC=C2)=O)=O)C[C@@H]3CCNC3=O)=O)CC4CC4)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MPro 13b

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.37 100

Preparing Stock Solutions for MPro 13b

The following data is based on the product molecular weight 593.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.68 mL 8.42 mL 16.84 mL
5 mM 0.34 mL 1.68 mL 3.37 mL
10 mM 0.17 mL 0.84 mL 1.68 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for MPro 13b

Certificate of Analysis / Product Datasheet
Select another batch:

References for MPro 13b

References are publications that support the biological activity of the product.

Zhang et al (2020) Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Science. 368 409 PMID: 32198291


If you know of a relevant reference for MPro 13b, please let us know.

View Related Products by Product Action

View all 3C and 3CL Protease Inhibitors

Keywords: MPro 13b, MPro 13b supplier, MPro13b, mpro, main, protease, proteinase, inhibitors, inhibits, sars-cov, mers-cov, sars-cov-2, coronavirus, 3C, and, 3CL, Proteases, Coronavirus, 7228, Tocris Bioscience

Citations for MPro 13b

Citations are publications that use Tocris products.

Currently there are no citations for MPro 13b. Do you know of a great paper that uses MPro 13b from Tocris? Please let us know.

Reviews for MPro 13b

There are currently no reviews for this product. Be the first to review MPro 13b and earn rewards!

Have you used MPro 13b?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation