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Biological Activity for MPro 13b
MPro 13b is a coronavirus Mpro inhibitor (IC50 values are 0.58, 0.9 and 0.67 μM for recombinant Mpro from MERS-CoV, SARS-CoV and SARS-CoV-2, respectively). Inhibits SARS-CoV-2 infection of human Calu3 cells (IC50 = 4-5 μM).
Please note, unpublished data suggest MPro 13b is 2-fold more potent than published data.
Sold under license from the University of Lübeck
Technical Data for MPro 13b
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MPro 13b
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MPro 13b
The following data is based on the product molecular weight 593.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.68 mL||8.42 mL||16.84 mL|
|5 mM||0.34 mL||1.68 mL||3.37 mL|
|10 mM||0.17 mL||0.84 mL||1.68 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
References for MPro 13b
References are publications that support the biological activity of the product.
Zhang et al (2020) Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Science. 368 409 PMID: 32198291
If you know of a relevant reference for MPro 13b, please let us know.
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Citations for MPro 13b
Citations are publications that use Tocris products.
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Literature in this Area
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