Discontinued Product

MPDC (Cat. No. 0973) has been withdrawn from sale for commercial reasons.
Cat.No. 0973 - MPDC | C7H9NO4 | CAS No. 159262-32-5
Description: Potent inhibitor of L-glutamate uptake. Less activity as a substrate compared to its parent compound, L-trans-2,4-PDC (Cat. No. 0298)
Chemical Name: L-anti-endo-3,4-Methanopyrrolidinedicarboxylic acid
Literature (4)

Biological Activity

Potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter.

Technical Data

M. Wt 171.15
Formula C7H9NO4
Storage Store at RT
CAS Number 159262-32-5
PubChem ID 6604785
Smiles [H][C@]1([C@H]2[C@@](O)=O)[C@]2([H])CN[C@@H]1[C@](O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.


References are publications that support the biological activity of the product.

Bridges et al (1994) A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: L-anti-endo-3,4-methanopyrrolidine carboxylate. Neurosci.Lett. 174 193 PMID: 7970177

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Keywords: MPDC, MPDC supplier, Potent, inhibitors, inhibits, L-glutamate, reuptake, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, 0973, Tocris Bioscience

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