MPDC

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Cat.No. 0973 - MPDC | C7H9NO4 | CAS No. 159262-32-5
Description: Potent inhibitor of L-glutamate uptake. Less activity as a substrate compared to its parent compound, L-trans-2,4-PDC (Cat. No. 0298)
Chemical Name: L-anti-endo-3,4-Methanopyrrolidinedicarboxylic acid
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter.

Technical Data

M. Wt 171.15
Formula C7H9NO4
Storage Store at RT
CAS Number 159262-32-5
PubChem ID 6604785
InChI Key UNNFLFDQCHJXPI-QTBDOELSSA-N
Smiles [H][C@]1([C@H]2[C@@](O)=O)[C@]2([H])CN[C@@H]1[C@](O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 171.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.84 mL 29.21 mL 58.43 mL
5 mM 1.17 mL 5.84 mL 11.69 mL
10 mM 0.58 mL 2.92 mL 5.84 mL
50 mM 0.12 mL 0.58 mL 1.17 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bridges et al (1994) A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: L-anti-endo-3,4-methanopyrrolidine carboxylate. Neurosci.Lett. 174 193 PMID: 7970177


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Keywords: MPDC, supplier, Potent, inhibitors, inhibits, L-glutamate, reuptake, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Glutamate, Transporters, Tocris Bioscience

Citations for MPDC

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Literature in this Area

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Pathways for MPDC

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