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Description: Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
Alternative Names: trans-4-Carboxy-L-proline
Chemical Name: L-trans-Pyrrolidine-2,4-dicarboxylic acid
Purity: ≥97% (HPLC)
Citations (4)
Literature (1)

Biological Activity for L-trans-2,4-PDC

L-trans-2,4-PDC is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. In [3H]-d-Asp uptake assays in HEK293 cells expressing human EAAT1, EAAT2 and EAAT3, Ki values are 20, 20 and 109 μM, respectively. In a FLIPR Membrane Potential (FMP) assay, Km values for L-trans-2,4-PDC are 7.7, 11 and 19 μM for human EAAT2, EAAT3 and EAAT1, respectively.

Technical Data for L-trans-2,4-PDC

M. Wt 159.14
Formula C6H9NO4
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 64769-66-0
PubChem ID 1515192
Smiles O=[C@]([C@H]1NC[C@H]([C@@](O)=O)C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-trans-2,4-PDC

Solvent Max Conc. mg/mL Max Conc. mM
water 15.91 100

Preparing Stock Solutions for L-trans-2,4-PDC

The following data is based on the product molecular weight 159.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.28 mL 31.42 mL 62.84 mL
5 mM 1.26 mL 6.28 mL 12.57 mL
10 mM 0.63 mL 3.14 mL 6.28 mL
50 mM 0.13 mL 0.63 mL 1.26 mL

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Product Datasheets for L-trans-2,4-PDC

Certificate of Analysis / Product Datasheet
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Keywords: L-trans-2,4-PDC, L-trans-2,4-PDC supplier, potent, competitive, Transportable, EAAT1-4, EAAT2, EAAT3, EAAT4, inhibitors, inhibits, non-transportable, EAAT5, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, reuptake, trans-4-Carboxy-L-proline, Acids, 0298, Tocris Bioscience

4 Citations for L-trans-2,4-PDC

Citations are publications that use Tocris products. Selected citations for L-trans-2,4-PDC include:

Yin and Weiss (2012) Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures. Brain Res 1448 153 PMID: 22370146

Heinrich et al (2012) K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. Br J Pharmacol 167 1003 PMID: 22394324

Beaulé et al (2009) Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes. PLoS One 4 e7476 PMID: 19829696

Young et al (2007) Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex. PLoS One 26 78 PMID: 17240155

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Huntington's Disease Poster

Huntington's Disease Poster

Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.