L-trans-2,4-PDC

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Cat.No. 0298 - L-trans-2,4-PDC | C6H9NO4 | CAS No. 64769-66-0
Description: Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
Alternative Names: trans-4-Carboxy-L-proline
Chemical Name: L-trans-Pyrrolidine-2,4-dicarboxylic acid
Purity: ≥97% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™.

Technical Data

M. Wt 159.14
Formula C6H9NO4
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 64769-66-0
PubChem ID 1515192
InChI Key NRSBQSJHFYZIPH-DMTCNVIQSA-N
Smiles O=[C@]([C@H]1NC[C@H]([C@@](O)=O)C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 15.91 100
1eq. NaOH 15.91 100
water 15.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 159.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.28 mL 31.42 mL 62.84 mL
5 mM 1.26 mL 6.28 mL 12.57 mL
10 mM 0.63 mL 3.14 mL 6.28 mL
50 mM 0.13 mL 0.63 mL 1.26 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bridges et al (1991) Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. J.Med.Chem. 34 717 PMID: 1671706

Mitrovic and Johnston (1994) Regional differences in the inhibition of L-glutamate amd L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylic threo-3-hydroxy-D-aspartate and D-aspartate. Neurochem.Int. 24 583 PMID: 7981641

Zuiderwijk et al (1996) Effects of uptake carrier blockers SK & F 89976-A and L-trans-PDC on in vivo release of amino acids in rat hippocampus. Eur.J.Pharmacol. 307 275 PMID: 8836615


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View Related Products by Product Action

View all Glutamate Transporter Inhibitors

Keywords: L-trans-2,4-PDC, supplier, potent, competitive, Transportable, EAAT1-4, EAAT2, EAAT3, EAAT4, inhibitors, inhibits, non-transportable, EAAT5, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, reuptake, trans-4-Carboxy-L-proline, Glutamate, Transporters, Glutamate, Transporters, Tocris Bioscience

4 Citations for L-trans-2,4-PDC

Citations are publications that use Tocris products. Selected citations for L-trans-2,4-PDC include:

Yin and Weiss (2012) Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures. Brain Res 1448 153 PMID: 22370146

Heinrich et al (2012) K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. Br J Pharmacol 167 1003 PMID: 22394324

Beaulé et al (2009) Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes. PLoS One 4 e7476 PMID: 19829696

Young et al (2007) Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex. PLoS One 26 78 PMID: 17240155


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