MP A08

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Description: Selective ATP competitive SphK1 and 2 inhibitor; cell permeable
Alternative Names: NSC 122314
Chemical Name: 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide

Biological Activity for MP A08

MP A08 is a selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.

Technical Data for MP A08

M. Wt 519.64
Formula C27H25N3O4S2
Storage Store at -20°C
CAS Number 219832-49-2
PubChem ID 420266
Smiles O=S(NC1=CC=CC=C1/N=C/C2=CC=CC=C2NS(C3=CC=C(C)C=C3)(=O)=O)(C4=CC=C(C)C=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MP A08

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.96 100

Preparing Stock Solutions for MP A08

The following data is based on the product molecular weight 519.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.92 mL 9.62 mL 19.24 mL
5 mM 0.38 mL 1.92 mL 3.85 mL
10 mM 0.19 mL 0.96 mL 1.92 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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References for MP A08

References are publications that support the biological activity of the product.

Pitman et al (2015) A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget 6 7065 PMID: 25788259

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Citations for MP A08

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