MP A08

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Cat.No. 5803 - MP A08 | C27H25N3O4S2 | CAS No. 219832-49-2
Description: Selective ATP competitive SphK1 and 2 inhibitor; cell permeable
Alternative Names: NSC 122314
Chemical Name: 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
Datasheet
Citations
Literature

Biological Activity

Selective ATP competitive sphingosine kinase 2 and 1 (SphK2/1) inhibitor (Ki values are 6.9 and 27 μM, respectively). Exhibits selectivity for SphK 1 and 2 over other kinases. Inhibits cellular S1P production and increases sphingosine and ceramide levels in vitro. Also induces mitochondrial-associated apoptosis. Reduces tumor growth in a human lung adenocarcinoma xenograft mouse model, by inducing apoptosis and suppressing angiogenesis. Cell permeable.

Technical Data

M. Wt 519.64
Formula C27H25N3O4S2
Storage Store at -20°C
CAS Number 219832-49-2
PubChem ID 420266
InChI Key FLDBNMYJUMAXDQ-UHFFFAOYSA-N
Smiles O=S(NC1=CC=CC=C1/N=C/C2=CC=CC=C2NS(C3=CC=C(C)C=C3)(=O)=O)(C4=CC=C(C)C=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 519.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.92 mL 9.62 mL 19.24 mL
5 mM 0.38 mL 1.92 mL 3.85 mL
10 mM 0.19 mL 0.96 mL 1.92 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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References

References are publications that support the products' biological activity.

Pitman et al (2015) A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget 6 7065 PMID: 25788259


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Keywords: MP A08, supplier, MPA08, Selective, ATP, competitive, sphingosine, kinase, 1, and, 2, SphK, sk1, sk2, cell, permeable, anticancer, apoptosis, apoptotic, NSC122314, NSC, 122314, Sphingosine, Kinase, Tocris Bioscience

Citations for MP A08

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

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