Moxonidine hydrochloride

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Cat.No. 2282 - Moxonidine hydrochloride | C9H12ClN5O.HCl | CAS No. 75536-04-8
Description: I1 receptor and α2-adrenoceptor agonist (I1 > α2)
Chemical Name: 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine hydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Mixed I1 imidazoline receptor and α2-adrenergic agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. Centrally acting antihypertensive agent.

Technical Data

M. Wt 278.14
Formula C9H12ClN5O.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 75536-04-8
PubChem ID 11231255
Smiles Cl.COC1=NC(C)=NC(Cl)=C1NC1=NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 27.81 100
DMSO 27.81 100

Preparing Stock Solutions

The following data is based on the product molecular weight 278.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.6 mL 17.98 mL 35.95 mL
5 mM 0.72 mL 3.6 mL 7.19 mL
10 mM 0.36 mL 1.8 mL 3.6 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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References are publications that support the biological activity of the product.

Schafer et al (2002) Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and α2-adrenoceptors. J.Pharmacol.Exp.Ther. 303 1163 PMID: 12438540

El-Ayoubi et al (2004) Imidazoline receptors but not a2-adrenoceptors are regulated in spontaneously hypertensive rat heart by chronic moxonidine treatment. J.Pharmacol.Exp.Ther. 310 446 PMID: 15075383

Chan et al (2005) Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clon. Neuroscience 132 991 PMID: 15857704

If you know of a relevant reference for Moxonidine hydrochloride, please let us know.

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