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Biological Activity for Mosapride citrate
Mosapride citrate is a 5-HT4 receptor agonist and 5-HT3 receptor antagonist. Displays no activity at D2, α1, α2, 5-HT1 and 5-HT2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.
Technical Data for Mosapride citrate
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Mosapride citrate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Mosapride citrate
The following data is based on the product molecular weight 614.02. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.63 mL||8.14 mL||16.29 mL|
|5 mM||0.33 mL||1.63 mL||3.26 mL|
|10 mM||0.16 mL||0.81 mL||1.63 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
Product Datasheets for Mosapride citrate
References for Mosapride citrate
References are publications that support the biological activity of the product.
Yoshida et al (1989) AS-4370, a novel gastrokinetic agent free of DA D2 receptor antagonist properties. Arch.Int.Pharmacodyn.Ther. 300 51 PMID: 2533479
Mine et al (1997) Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J.Pharmacol.Exp.Ther. 283 1000 PMID: 9399969
Yoshida et al (1993) Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals. Arzneim.-Forsch. 43 1078
If you know of a relevant reference for Mosapride citrate, please let us know.
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Citations for Mosapride citrate
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.