Mosapride citrate

Pricing Availability Delivery Time Qty
Cat.No. 2844 - Mosapride citrate | C21H25ClFN3O3.C6H8O7 | CAS No. 112885-42-4
Description: 5-HT4 agonist and 5-HT3 antagonist
Chemical Name: 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamide citrate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

5-HT4 receptor agonist and 5-HT3 receptor antagonist. Displays no activity at D2, α1, α2, 5-HT1 and 5-HT2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.

Compound Libraries

Mosapride citrate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 614.02
Formula C21H25ClFN3O3.C6H8O7
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 112885-42-4
PubChem ID 119583
InChI Key HUZTYZBFZKRPFG-UHFFFAOYSA-N
Smiles O=C(O)C(O)(CC(O)=O)CC(O)=O.ClC1=C(N)C=C(OCC)C(C(NCC2OCCN(CC3=CC=C(F)C=C3)C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 61.4 100
ethanol 6.14 10

Preparing Stock Solutions

The following data is based on the product molecular weight 614.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.14 mL 16.29 mL
5 mM 0.33 mL 1.63 mL 3.26 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yoshida et al (1989) AS-4370, a novel gastrokinetic agent free of dopamine D2 receptor antagonist properties. Arch.Int.Pharmacodyn.Ther. 300 51 PMID: 2533479

Mine et al (1997) Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J.Pharmacol.Exp.Ther. 283 1000 PMID: 9399969

Yoshida et al (1993) Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals. Arzneim.-Forsch. 43 1078 PMID:


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Keywords: Mosapride citrate, supplier, 5-HT3, antagonists, 5-HT4, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT4, Receptors, Tocris Bioscience

Citations for Mosapride citrate

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