Montelukast sodium

Pricing Availability   Qty
Description: CysLT1 and GPR17 antagonist
Chemical Name: 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity for Montelukast sodium

Montelukast sodium is a cysteinyl leukotriene receptor 1 (CysLT1) and GPR17 antagonist. Blocks pentylenetetrazole-induced seizures, blood brain barrier (BBB) disruption and leukocyte migration in mice. Reduces neuroinflammation, improves BBB integrity, enhances learning and memory, and restores hippocampal neurogenesis and cognitive function in aged rats. Orally active and brain penetrant.

Compound Libraries for Montelukast sodium

Montelukast sodium is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Montelukast sodium

M. Wt 608.17
Formula C35H35ClNNaO3S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 151767-02-1
PubChem ID 23663996
InChI Key LBFBRXGCXUHRJY-HKHDRNBDSA-M
Smiles CC(O)(C1=C(C=CC=C1)CC[C@H](C2=CC(/C=C/C3=NC4=CC(Cl)=CC=C4C=C3)=CC=C2)SCC5(CC5)CC(O[Na])=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Montelukast sodium

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.41 50
DMSO 60.82 100

Preparing Stock Solutions for Montelukast sodium

The following data is based on the product molecular weight 608.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.22 mL 16.44 mL
5 mM 0.33 mL 1.64 mL 3.29 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets for Montelukast sodium

References for Montelukast sodium

References are publications that support the biological activity of the product.

Lenz et al (2014) Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction. Neuroscience 277 859 PMID: 25090924

Marschallinger et al (2015) Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat.Commun. 6 8466 PMID: 26506265


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View all Leukotriene and Related Receptor Antagonists

Keywords: Montelukast sodium, Montelukast sodium supplier, Leukotriene, D4, antagonists, antagonism, cysteinyl, receptors, CysLT1, seizures, blood, brain, barrier, disruption, epilepsy, GPR17, and, Related, Receptors, 5904, Tocris Bioscience

1 Citation for Montelukast sodium

Citations are publications that use Tocris products. Selected citations for Montelukast sodium include:

Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem Biophys Res Commun 520 35 PMID: 31564414


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Literature in this Area

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