Moexipril hydrochloride

Discontinued Product

Moexipril hydrochloride (Cat. No. 2691) has been withdrawn from sale for commercial reasons.
Cat.No. 2691 - Moexipril hydrochloride | C27H34N2O7.HCl | CAS No. 82586-52-5
Description: Angiotensin-converting enzyme (ACE) inhibitor
Alternative Names: RS 10085
Chemical Name: 2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Angiotensin-converting enzyme (ACE) inhibitor that is hydrolyzed in the liver to the active metabolite moexiprilat (IC50 values are 2.1 and 2700 nM for moexiprilat and moexipril respectively). Antihypertensive; decreases mean blood pressure in the spontaneous hypertensive rat (SHR). Also blocks degradation of bradykinin into inactive metabolites.

Technical Data

M. Wt 535.03
Formula C27H34N2O7.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 82586-52-5
PubChem ID 54889
InChI Key JXRAXHBVZQZSIC-JKVLGAQCSA-N
Smiles O=C([C@@H](N[C@H]([C@@](OCC)=O)CCC3=CC=CC=C3)C)N2CC1=CC(OC)=C(OC)C=C1C[C@H]2[C@@](O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Edling et al (1995) Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enal. J.Pharmacol.Exp.Ther. 275 854 PMID: 7473177

Chrysant and Chrysant (2004) Pharmacological and clinical profile of moexipril: a concise review. J.Clin.Pharmacol. 44 827 PMID: 15286086

Friehe and Ney (1997) Pharmacological and toxicological studies of the new angiotensin converting enzyme inhibitor moex. hydrochloride. Arzneim.-Forsch. 47 132

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Citations for Moexipril hydrochloride

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Literature in this Area

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Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure