Moexipril hydrochloride

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Cat.No. 2691 - Moexipril hydrochloride | C27H34N2O7.HCl | CAS No. 82586-52-5
Description: Angiotensin-converting enzyme (ACE) inhibitor
Alternative Names: RS 10085
Chemical Name: 2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Angiotensin-converting enzyme (ACE) inhibitor that is hydrolyzed in the liver to the active metabolite moexiprilat (IC50 values are 2.1 and 2700 nM for moexiprilat and moexipril respectively). Antihypertensive; decreases mean blood pressure in the spontaneous hypertensive rat (SHR). Also blocks degradation of bradykinin into inactive metabolites.

Technical Data

M. Wt 535.03
Formula C27H34N2O7.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 82586-52-5
PubChem ID 54889
InChI Key JXRAXHBVZQZSIC-JKVLGAQCSA-N
Smiles O=C([C@@H](N[C@H]([C@@](OCC)=O)CCC3=CC=CC=C3)C)N2CC1=CC(OC)=C(OC)C=C1C[C@H]2[C@@](O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.5 100
ethanol 53.5 100
water 53.5 100

Preparing Stock Solutions

The following data is based on the product molecular weight 535.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.35 mL 18.69 mL
5 mM 0.37 mL 1.87 mL 3.74 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Edling et al (1995) Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril. J.Pharmacol.Exp.Ther. 275 854 PMID: 7473177

Chrysant and Chrysant (2004) Pharmacological and clinical profile of moexipril: a concise review. J.Clin.Pharmacol. 44 827 PMID: 15286086

Friehe and Ney (1997) Pharmacological and toxicological studies of the new angiotensin converting enzyme inhibitor moexipril hydrochloride. Arzneim.-Forsch. 47 132 PMID:


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Citations for Moexipril hydrochloride

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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

Pathways for Moexipril hydrochloride

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