ML 349

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Cat.No. 5344 - ML 349 | C23H22N2O4S2 | CAS No. 890819-86-0
Description: Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor
Chemical Name: (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor (IC50 = 144 nM). Displays selectively over LYPLA1 and 20 other serine hydrolases (IC50 values are >3000 and >10,000 nM respectively).

Technical Data

M. Wt 454.56
Formula C23H22N2O4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 890819-86-0
PubChem ID 16193817
InChI Key YVIJPELUPZUEJX-UHFFFAOYSA-N
Smiles COC1=CC=C(N2CCN(C(C3=CC4=C(C(C=CC=C5)=C5S(C4)(=O)=O)S3)=O)CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.09 20

Preparing Stock Solutions

The following data is based on the product molecular weight 454.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11 mL 55 mL 110 mL
1 mM 2.2 mL 11 mL 22 mL
2 mM 1.1 mL 5.5 mL 11 mL
10 mM 0.22 mL 1.1 mL 2.2 mL

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References

References are publications that support the biological activity of the product.

Adibekian et al (2010) Characterization of a selective, reversible inhibitor of lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program PMID: 24624468

Hernandez et al (2017) APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Che.Bio. 24 87 PMID: 28065656


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Keywords: ML 349, ML 349 supplier, ML349, selective, reversible, Lysophospholipase, 2, LYPLA2, inhibitors, inhibits, serine, hydrolases, APT2, protein, acyl, thioesterase, Other, Hydrolases, 5344, Tocris Bioscience

1 Citation for ML 349

Citations are publications that use Tocris products. Selected citations for ML 349 include:

Vujic et al (2016) Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget 7 7297 PMID: 26771141


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Literature in this Area

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