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Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor (IC50 = 144 nM). Displays selectively over LYPLA1 and 20 other serine hydrolases (IC50 values are >3000 and >10,000 nM respectively).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 454.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11 mL||55 mL||110 mL|
|1 mM||2.2 mL||11 mL||22 mL|
|2 mM||1.1 mL||5.5 mL||11 mL|
|10 mM||0.22 mL||1.1 mL||2.2 mL|
References are publications that support the biological activity of the product.
Adibekian et al (2010) Characterization of a selective, reversible inhibitor of lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program PMID: 24624468
Hernandez et al (2017) APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Che.Bio. 24 87 PMID: 28065656
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Keywords: ML 349, ML 349 supplier, ML349, selective, reversible, Lysophospholipase, 2, LYPLA2, inhibitors, inhibits, serine, hydrolases, APT2, protein, acyl, thioesterase, Other, Hydrolases, 5344, Tocris Bioscience
1 Citation for ML 349
Citations are publications that use Tocris products. Selected citations for ML 349 include:
Vujic et al (2016) Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget 7 7297 PMID: 26771141
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