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Submit ReviewML 348
Description: Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor
Chemical Name: N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide
Purity: ≥99% (HPLC)
Biological Activity for ML 348
ML 348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases.
Compound Libraries for ML 348
ML 348 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ML 348
| M. Wt | 415.79 |
| Formula | C18H17ClF3N3O3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 899713-86-1 |
| PubChem ID | 3238952 |
| InChI Key | OXKNHBBDOIMFFQ-UHFFFAOYSA-N |
| Smiles | ClC1=C(NC(CN2CCN(C(C3=CC=CO3)=O)CC2)=O)C=C(C(F)(F)F)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ML 348
References for ML 348
References are publications that support the biological activity of the product.
Adibekian et al (2013) Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program PMID: 24624465
Hernandez et al (2017) APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Chem.Bio. 24 87 PMID: 28065656
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Keywords: ML 348, ML 348 supplier, ML348, selective, reversible, lysophospholipase, 1, lypla1, inhibitors, inhibits, APT1, acyl, protein, thioesterase, Other, Hydrolases, 5345, Tocris Bioscience
3 Citations for ML 348
Citations are publications that use Tocris products. Selected citations for ML 348 include:
Zingler et al (2019) Palmitoylation is required for TNF-R1 signaling. Cell Commun Signal 17 90 PMID: 31382980
Vujic et al (2016) Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget 7 7297 PMID: 26771141
Francisco S et al (2021) Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains. Nat Chem Biol 17 438-447 PMID: 33707782
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