ML 348

Pricing Availability   Qty
Description: Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor
Chemical Name: N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for ML 348

ML 348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases.

Compound Libraries for ML 348

ML 348 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 348

M. Wt 415.79
Formula C18H17ClF3N3O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 899713-86-1
PubChem ID 3238952
Smiles ClC1=C(NC(CN2CCN(C(C3=CC=CO3)=O)CC2)=O)C=C(C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 348

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.58 100

Preparing Stock Solutions for ML 348

The following data is based on the product molecular weight 415.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.03 mL 24.05 mL
5 mM 0.48 mL 2.41 mL 4.81 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References for ML 348

References are publications that support the biological activity of the product.

Adibekian et al (2013) Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program PMID: 24624465

Hernandez et al (2017) APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Chem.Bio. 24 87 PMID: 28065656

If you know of a relevant reference for ML 348, please let us know.

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Keywords: ML 348, ML 348 supplier, ML348, selective, reversible, lysophospholipase, 1, lypla1, inhibitors, inhibits, APT1, acyl, protein, thioesterase, Other, Hydrolases, 5345, Tocris Bioscience

2 Citations for ML 348

Citations are publications that use Tocris products. Selected citations for ML 348 include:

Zingler et al (2019) Palmitoylation is required for TNF-R1 signaling. Cell Commun Signal 17 90 PMID: 31382980

Vujic et al (2016) Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget 7 7297 PMID: 26771141

Do you know of a great paper that uses ML 348 from Tocris? Please let us know.

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