ML 348

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Cat.No. 5345 - ML 348 | C18H17ClF3N3O3 | CAS No. 899713-86-1
Description: Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor
Chemical Name: N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases.

Compound Libraries

ML 348 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 415.79
Formula C18H17ClF3N3O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 899713-86-1
PubChem ID 3238952
InChI Key OXKNHBBDOIMFFQ-UHFFFAOYSA-N
Smiles ClC1=C(NC(CN2CCN(C(C3=CC=CO3)=O)CC2)=O)C=C(C(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 415.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.03 mL 24.05 mL
5 mM 0.48 mL 2.41 mL 4.81 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Adibekian et al (2013) Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program PMID: 24624465


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View all Other Hydrolase Inhibitors

Keywords: ML348 selective reversible lysophospholipase 1 lypla1 inhibitors inhibits Other Hydrolases

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