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ML 348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases.
ML 348 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 415.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.41 mL||12.03 mL||24.05 mL|
|5 mM||0.48 mL||2.41 mL||4.81 mL|
|10 mM||0.24 mL||1.2 mL||2.41 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the biological activity of the product.
Adibekian et al (2013) Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program PMID: 24624465
Hernandez et al (2017) APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells. Cell Chem.Bio. 24 87 PMID: 28065656
If you know of a relevant reference for ML 348, please let us know.
Keywords: ML 348, ML 348 supplier, ML348, selective, reversible, lysophospholipase, 1, lypla1, inhibitors, inhibits, APT1, acyl, protein, thioesterase, Other, Hydrolases, 5345, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for ML 348 include:
Zingler et al (2019) Palmitoylation is required for TNF-R1 signaling. Cell Commun Signal 17 90 PMID: 31382980
Vujic et al (2016) Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget 7 7297 PMID: 26771141
Do you know of a great paper that uses ML 348 from Tocris? Please let us know.
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