Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 446.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.24 mL||11.2 mL||22.4 mL|
|5 mM||0.45 mL||2.24 mL||4.48 mL|
|10 mM||0.22 mL||1.12 mL||2.24 mL|
|50 mM||0.04 mL||0.22 mL||0.45 mL|
References are publications that support the biological activity of the product.
Hu et al (2013) Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg.Med.Chem.Lett. 23 3039 PMID: 23562243
Rosini et al (2014) Oxidative stress in Alzheimer's disease: are we connecting the dots? J.Med.Chem. 57 2821 PMID: 24131448
If you know of a relevant reference for ML 334, please let us know.
View Related Products by Product Action
Keywords: ML 334, ML 334 supplier, ML334, Keap1, Nrf2, interaction, inhibitors, inhibits, inhibts, cell, permeable, nuclear, factor, erythroid-derived, 2, like, Kelch, like-ECH-associated, protein, 1, LH601A, 5625, Tocris Bioscience
Citations for ML 334
Citations are publications that use Tocris products.
Currently there are no citations for ML 334. Do you know of a great paper that uses ML 334 from Tocris? Please let us know.
Reviews for ML 334
There are currently no reviews for this product. Be the first to review ML 334 and earn rewards!
Have you used ML 334?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.