Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewML 334
Description: Inhibitor of Keap1- Nrf2 interaction
Alternative Names: LH601A
Chemical Name: (1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for ML 334
ML 334 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable.
Technical Data for ML 334
| M. Wt | 446.5 |
| Formula | C26H26N2O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1432500-66-7 |
| PubChem ID | 56840728 |
| InChI Key | LNENLABLFGGAFF-BHIFYINESA-N |
| Smiles | O=C([C@@H]1CCCC[C@@H]1C(O)=O)N2CCC3=CC=CC=C3[C@H]2CN4C(C(C=CC=C5)=C5C4=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 334
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.65 | 100 |
Preparing Stock Solutions for ML 334
The following data is based on the product molecular weight 446.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.2 mL | 22.4 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for ML 334
References for ML 334
References are publications that support the biological activity of the product.
Hu et al (2013) Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg.Med.Chem.Lett. 23 3039 PMID: 23562243
Rosini et al (2014) Oxidative stress in Alzheimer's disease: are we connecting the dots? J.Med.Chem. 57 2821 PMID: 24131448
If you know of a relevant reference for ML 334, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ML 334, ML 334 supplier, ML334, Keap1, Nrf2, interaction, inhibitors, inhibits, inhibts, cell, permeable, nuclear, factor, erythroid-derived, 2, like, Kelch, like-ECH-associated, protein, 1, LH601A, 5625, Tocris Bioscience
1 Citation for ML 334
Citations are publications that use Tocris products. Selected citations for ML 334 include:
Vladimir et al (2021) A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy. Redox Biol 48 102186 PMID: 34801863
Do you know of a great paper that uses ML 334 from Tocris? Please let us know.
Reviews for ML 334
There are currently no reviews for this product. Be the first to review ML 334 and earn rewards!
Have you used ML 334?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.