ML 334

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Cat.No. 5625 - ML 334 | C26H26N2O5 | CAS No. 1432500-66-7
Description: Inhibitor of Keap1- Nrf2 interaction
Alternative Names: LH601A
Chemical Name: (1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid
Purity: ≥98% (HPLC)

Biological Activity

Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable.

Technical Data

M. Wt 446.5
Formula C26H26N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1432500-66-7
PubChem ID 56840728
Smiles O=C([C@@H]1CCCC[C@@H]1C(O)=O)N2CCC3=CC=CC=C3[C@H]2CN4C(C(C=CC=C5)=C5C4=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.65 100
ethanol 44.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 446.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.2 mL 22.4 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Hu et al (2013) Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg.Med.Chem.Lett. 23 3039 PMID: 23562243

Rosini et al (2014) Oxidative stress in Alzheimer's disease: are we connecting the dots? J.Med.Chem. 57 2821 PMID: 24131448

If you know of a relevant reference for ML 334, please let us know.

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Keywords: ML334 Keap1 Nrf2 interaction inhibitors inhibits inhibts cell permeable nuclear factor erythroid-derived 2 like 2 Kelch like-ECH-associated protein 1 LH601A Nrf2

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Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

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