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ML 311

Cat. No. 5733 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Inhibits Mcl-1-BIM interaction
Chemical Name: 7-[(4-Ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ML 311

ML 311 is an inhibits Mcl1-BIM interaction. Inhibits viability of Mcl1-dependent tumor cell lines. Induces cell death and decreased spheroid formation in Her2 positive breast cancer cells.

Technical Data for ML 311

M. Wt 415.45
Formula C23H24F3N3O
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 315698-17-0
PubChem ID 3384730
InChI Key NGAPBLRRJSKIRT-UHFFFAOYSA-N
Smiles CCN(CC1)CCN1C(C2=CC=C(C(F)(F)F)C=C2)C3=C(O)C4=NC=CC=C4C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 311

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.77 50
ethanol 20.77 50

Preparing Stock Solutions for ML 311

The following data is based on the product molecular weight 415.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.81 mL 24.07 mL 48.14 mL
2.5 mM 0.96 mL 4.81 mL 9.63 mL
5 mM 0.48 mL 2.41 mL 4.81 mL
25 mM 0.1 mL 0.48 mL 0.96 mL

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References for ML 311

References are publications that support the biological activity of the product.

Bashari et al (2016) Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications. Breast Cancer Res. 18 26 PMID: 26921175

Bannister et al (2012) ML311: A small molecule that potently and selectively disrupts the protein-protein interaction of Mcl-1 and Bim: a probe for studying lymphoid tumorigenesis. Probe Reports from the NIH Molecular Libraries Program PMID: 23762927

If you know of a relevant reference for ML 311, please let us know.

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Keywords: ML 311, ML 311 supplier, ML311, myeloid, cell, leukemia, 1, mcl1, BIM, inhibitors, inhibits, interaction, Bcl-2, Family, 5733, Tocris Bioscience

Citations for ML 311

Citations are publications that use Tocris products.

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Reviews for ML 311

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Literature in this Area

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Pathways for ML 311

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