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Biological Activity for ML 18
Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM). Also binds GRPR (IC50 = 16 μM). Inhibits BA1-stimulated cytosolic Ca2+ and suppresses cell proliferation in a lung cancer model in vitro.
Technical Data for ML 18
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for ML 18
References are publications that support the biological activity of the product.
Moody et al (2015) ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides 64 55 PMID: 25554218
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Keywords: ML 18, ML 18 supplier, ML18, Bombesin, receptors, BRS, 3, PD168368, neuromedin, B, NMBR, gastrin, releasing, peptide, GRPR, lung, cancer, Receptors, 5599, Tocris Bioscience
Citations for ML 18
Citations are publications that use Tocris products.
Currently there are no citations for ML 18.
Reviews for ML 18
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.