ML 18

Discontinued Product

ML 18 (Cat. No. 5599) has been withdrawn from sale for commercial reasons.
Description: BRS-3 antagonist; also GRPR agonist
Chemical Name: (αS)-N-[[1-(4-Methoxyphenyl)cyclohexyl]methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-1H-indole-3-propanamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for ML 18

Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM). Also binds GRPR (IC50 = 16 μM). Inhibits BA1-stimulated cytosolic Ca2+ and suppresses cell proliferation in a lung cancer model in vitro.

Technical Data for ML 18

M. Wt 569.65
Formula C32H35N5O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1422269-30-4
PubChem ID 91827363
Smiles O=C(NCC1(C2=CC=C(OC)C=C2)CCCCC1)[C@@H](NC(NC3=CC=C([N+]([O-])=O)C=C3)=O)CC4=CNC5=CC=CC=C54

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ML 18

References are publications that support the biological activity of the product.

Moody et al (2015) ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides 64 55 PMID: 25554218

View Related Products by Target

View Related Products by Product Action

View all Bombesin Receptor Antagonists

Keywords: ML 18, ML 18 supplier, ML18, Bombesin, receptors, BRS, 3, PD168368, neuromedin, B, NMBR, gastrin, releasing, peptide, GRPR, lung, cancer, Receptors, 5599, Tocris Bioscience

Citations for ML 18

Citations are publications that use Tocris products.

Currently there are no citations for ML 18.

Reviews for ML 18

There are currently no reviews for this product. Be the first to review ML 18 and earn rewards!

Have you used ML 18?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.