ML 18

Discontinued Product

ML 18 (Cat. No. 5599) has been withdrawn from sale for commercial reasons.
Cat.No. 5599 - ML 18 | C32H35N5O5 | CAS No. 1422269-30-4
Description: BRS-3 antagonist; also GRPR agonist
Chemical Name: (αS)-N-[[1-(4-Methoxyphenyl)cyclohexyl]methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-1H-indole-3-propanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM). Also binds GRPR (IC50 = 16 μM). Inhibits BA1-stimulated cytosolic Ca2+ and suppresses cell proliferation in a lung cancer model in vitro.

Technical Data

M. Wt 569.65
Formula C32H35N5O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1422269-30-4
PubChem ID 91827363
InChI Key JOKVJNCYOSFDGC-LJAQVGFWSA-N
Smiles O=C(NCC1(C2=CC=C(OC)C=C2)CCCCC1)[C@@H](NC(NC3=CC=C([N+]([O-])=O)C=C3)=O)CC4=CNC5=CC=CC=C54

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Moody et al (2015) ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides 64 55 PMID: 25554218

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Keywords: ML 18, ML 18 supplier, ML18, Bombesin, receptors, BRS, 3, PD168368, neuromedin, B, NMBR, gastrin, releasing, peptide, GRPR, lung, cancer, Receptors, 5599, Tocris Bioscience

Citations for ML 18

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Currently there are no citations for ML 18.

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Literature in this Area

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