BA 1

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Cat.No. 5600 - BA 1 | D-Tyr-Gln-Trp-Ala-Val-β-Ala-His-Phe-Nle-NH2 | CAS No. 183241-31-8
Description: Potent BRS-3 agonist; also NMBR and GRPR agonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent bombesin receptor subtype 3 (BRS-3; BB3) agonist (IC50 = 2.52 nM). Also GRPR (BB1) and NMBR (BB2) agonist (IC50 values are 0.26 and 1.55 nM respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 lung cancer cell proliferation in vitro.

Technical Data

M. Wt 1133.32
Formula C57H76N14O11
Sequence YQWAVAHFX

(Modifications: Tyr-1= D-Tyr, Ala-6 = β-Ala, X = Nle, Nle-9 = C-terminal amide)

Storage Store at -20°C
CAS Number 183241-31-8
PubChem ID 91826107
InChI Key BXSSCSKCOFKPOK-ZWAOGYCRSA-N
Smiles [H]N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

References

References are publications that support the biological activity of the product.

González et al (2015) Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes Int.J.Mol.Med. 35 925 PMID: 25653074

Moody et al (2015) ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides 64 55 PMID: 25554218

Moreno et al (2013) Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors. J.Pharmacol.Exp.Ther. 347 100 PMID: 23892571

Mantey et al (1997) Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. J Biol Chem. 272 26062 PMID: 9325344


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Keywords: BA 1, BA 1 supplier, BA1, bombesin, receptors, subtype3, BRS3, BB3, BB1, BB2, neuromedinB, NMBR, GRPR, gastrin-releasing, peptides, hormones, Bombesin, Receptors, 5600, Tocris Bioscience

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