BA 1

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Cat.No. 5600 - BA 1 | D-Tyr-Gln-Trp-Ala-Val-β-Ala-His-Phe-Nle-NH2 | CAS No. 183241-31-8
Description: Potent bombesin agonist
Citations (1)
Literature (3)

Biological Activity

Potent bombesin receptor agonist (IC50 values are 0.26, 1.55 and 2.52 nM for BB1, BB2 and BB3 respectively). Enhances glucose transport in obese and diabetic primary myocytes. Also stimulates NCI-H1299 lung cancer cell proliferation in vitro.

Technical Data

M. Wt 1133.32
Formula C57H76N14O11

(Modifications: Tyr-1= D-Tyr, Ala-6 = β-Ala, X = Nle, Nle-9 = C-terminal amide)

Storage Store at -20°C
CAS Number 183241-31-8
PubChem ID 91826107
Smiles [H]N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water


References are publications that support the biological activity of the product.

González et al (2015) Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes Int.J.Mol.Med. 35 925 PMID: 25653074

Moody et al (2015) ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides 64 55 PMID: 25554218

Moreno et al (2013) Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors. J.Pharmacol.Exp.Ther. 347 100 PMID: 23892571

Mantey et al (1997) Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors. J Biol Chem. 272 26062 PMID: 9325344

If you know of a relevant reference for BA 1, please let us know.

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Keywords: BA 1, BA 1 supplier, BA1, bombesin, receptors, subtype3, BRS3, BB3, BB1, BB2, neuromedinB, NMBR, GRPR, gastrin-releasing, peptides, hormones, Bombesin, Receptors, 5600, Tocris Bioscience

1 Citation for BA 1

Citations are publications that use Tocris products. Selected citations for BA 1 include:

Acuña et al (2019) Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates. Cells 8 PMID: 31349736

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Literature in this Area

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