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ML 179 is a selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 422.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.73 mL||23.67 mL||47.34 mL|
|2.5 mM||0.95 mL||4.73 mL||9.47 mL|
|5 mM||0.47 mL||2.37 mL||4.73 mL|
|25 mM||0.09 mL||0.47 mL||0.95 mL|
References are publications that support the biological activity of the product.
Busby et al (2010) Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2). Probe Reports from the NIH Molecular Libraries Program PMID: 23166964
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Keywords: ML 179, ML 179 supplier, ML179, Selective, inverse, agonists, agonism, liver, receptor, homolog-1, LRH1, Other, Nuclear, Receptors, 4957, Tocris Bioscience
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breast cancer cells line
Dilution buffer 100% DMSO for a stock solution at 10mM, used in a cell line where it showed a potent activity (breast cancer cells; IC50 values of 370nM).
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