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Biological Activity for ML 179
ML 179 is a selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.
Technical Data for ML 179
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 179
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ML 179
The following data is based on the product molecular weight 422.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.73 mL||23.67 mL||47.34 mL|
|2.5 mM||0.95 mL||4.73 mL||9.47 mL|
|5 mM||0.47 mL||2.37 mL||4.73 mL|
|25 mM||0.09 mL||0.47 mL||0.95 mL|
References for ML 179
References are publications that support the biological activity of the product.
Busby et al (2010) Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2). Probe Reports from the NIH Molecular Libraries Program PMID: 23166964
If you know of a relevant reference for ML 179, please let us know.
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Keywords: ML 179, ML 179 supplier, ML179, Selective, inverse, agonists, agonism, liver, receptor, homolog-1, LRH1, Other, Nuclear, Receptors, 4957, Tocris Bioscience
Citations for ML 179
Citations are publications that use Tocris products.
Currently there are no citations for ML 179. Do you know of a great paper that uses ML 179 from Tocris? Please let us know.
Reviews for ML 179
Average Rating: 4 (Based on 1 Review.)
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breast cancer cells line
Dilution buffer 100% DMSO for a stock solution at 10mM, used in a cell line where it showed a potent activity (breast cancer cells; IC50 values of 370nM).
Literature in this Area
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