ML 179

Pricing Availability   Qty
Cat.No. 4957 - ML 179 | C21H25F3N4O2
Description: Selective liver receptor homolog 1 (LRH1) inverse agonist
Chemical Name: 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.

Compound Libraries

ML 179 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 422.44
Formula C21H25F3N4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
PubChem ID 45100448
InChI Key MFABFKUNLDYKGH-UHFFFAOYSA-N
Smiles O=C(C=C(N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)NC2=O)N2C1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.12 50

Preparing Stock Solutions

The following data is based on the product molecular weight 422.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.73 mL 23.67 mL 47.34 mL
2.5 mM 0.95 mL 4.73 mL 9.47 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
25 mM 0.09 mL 0.47 mL 0.95 mL

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Busby et al (2010) Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2). Probe Reports from the NIH Molecular Libraries Program PMID: 23166964


If you know of a relevant reference for ML 179, please let us know.

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Keywords: ML 179, ML 179 supplier, ML179, Selective, inverse, agonists, agonism, liver, receptor, homolog-1, LRH1, Other, Nuclear, Receptors, 4957, Tocris Bioscience

Citations for ML 179

Citations are publications that use Tocris products.

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Reviews for ML 179

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Selective liver receptor homolog 1 (LRH1) inverse agonist
By Anonymous on 11/16/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: BT-474

breast cancer cells line

Dilution buffer 100% DMSO for a stock solution at 10mM, used in a cell line where it showed a potent activity (breast cancer cells; IC50 values of 370nM).


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