ML 179

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Cat.No. 4957 - ML 179 | C21H25F3N4O2
Description: Selective liver receptor homolog 1 (LRH1) inverse agonist
Chemical Name: 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.

Compound Libraries

ML 179 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 422.44
Formula C21H25F3N4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
PubChem ID 45100448
InChI Key MFABFKUNLDYKGH-UHFFFAOYSA-N
Smiles O=C(C=C(N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)NC2=O)N2C1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.12 50

Preparing Stock Solutions

The following data is based on the product molecular weight 422.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.84 mL 23.67 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Busby et al (2010) Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2). Probe Reports from the NIH Molecular Libraries Program PMID: 23166964


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Keywords: ML 179, supplier, ML179, Selective, inverse, agonists, agonism, liver, receptor, homolog-1, LRH1, Other, Nuclear, Receptors, Other, Nuclear, Receptors, Tocris Bioscience

Citations for ML 179

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