ML 179

Pricing Availability   Qty
Description: Selective liver receptor homolog 1 (LRH1) inverse agonist
Chemical Name: 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione
Purity: ≥99% (HPLC)
Reviews (1)

Biological Activity for ML 179

ML 179 is a selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50 = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.

Technical Data for ML 179

M. Wt 422.44
Formula C21H25F3N4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1883548-87-5
PubChem ID 45100448
Smiles O=C(C=C(N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)NC2=O)N2C1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 179

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 21.12 50

Preparing Stock Solutions for ML 179

The following data is based on the product molecular weight 422.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.73 mL 23.67 mL 47.34 mL
2.5 mM 0.95 mL 4.73 mL 9.47 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
25 mM 0.09 mL 0.47 mL 0.95 mL

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References for ML 179

References are publications that support the biological activity of the product.

Busby et al (2010) Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2). Probe Reports from the NIH Molecular Libraries Program PMID: 23166964

If you know of a relevant reference for ML 179, please let us know.

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Keywords: ML 179, ML 179 supplier, ML179, Selective, inverse, agonists, agonism, liver, receptor, homolog-1, LRH1, Other, Nuclear, Receptors, 4957, Tocris Bioscience

Citations for ML 179

Citations are publications that use Tocris products.

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Reviews for ML 179

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Selective liver receptor homolog 1 (LRH1) inverse agonist.
By Anonymous on 11/16/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: BT-474

breast cancer cells line

Dilution buffer 100% DMSO for a stock solution at 10mM, used in a cell line where it showed a potent activity (breast cancer cells; IC50 values of 370nM).