ML 171

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Cat.No. 4653 - ML 171 | C14H11NOS | CAS No. 6631-94-3
Description: Selective NADPH oxidase 1 (NOX1) inhibitor
Chemical Name: 2-Acetylphenothiazine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

NADPH oxidase 1 (NOX1) inhibitor; blocks NOX1-dependent ROS generation (IC50 = 0.25 μM in a HEK293-NOX1 recombinant cell system). Selective for NOX1 over other NADPH oxidases (IC50 values are > 3 μM). Inhibits SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.

Technical Data

M. Wt 241.31
Formula C14H11NOS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6631-94-3
PubChem ID 81131
InChI Key JWGBOHJGWOPYCL-UHFFFAOYSA-N
Smiles CC(C1=CC2=C(C=C1)SC3=CC=CC=C3N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.13 100
ethanol 1.21 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 241.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.14 mL 20.72 mL 41.44 mL
5 mM 0.83 mL 4.14 mL 8.29 mL
10 mM 0.41 mL 2.07 mL 4.14 mL
50 mM 0.08 mL 0.41 mL 0.83 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gianni et al (2010) A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem.Biol. 5 981 PMID: 20715845

Drummond et al (2011) Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat.Rev.Drug Discov. 10 453 PMID: 21629295


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Keywords: ML 171, supplier, ML171, NADPH, oxidases, 1, NOX1, reactive, oxygen, species, ROS, inhibits, inhibitors, selective, cell, permeable, NADPH, Oxidase, NADPH, Oxidase, Tocris Bioscience

1 Citation for ML 171

Citations are publications that use Tocris products. Selected citations for ML 171 include:

Cheung et al (2016) Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Anal Bioanal Chem 30 52 PMID: 26679840


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