NADPH oxidase 1 (NOX1) inhibitor; blocks NOX1-dependent ROS generation (IC50 = 0.25 μM in a HEK293-NOX1 recombinant cell system). Selective for NOX1 over other NADPH oxidases (IC50 values are > 3 μM). Inhibits SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||1.21||5mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 241.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.14 mL||20.72 mL||41.44 mL|
|5 mM||0.83 mL||4.14 mL||8.29 mL|
|10 mM||0.41 mL||2.07 mL||4.14 mL|
|50 mM||0.08 mL||0.41 mL||0.83 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Gianni et al (2010) A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem.Biol. 5 981 PMID: 20715845
Drummond et al (2011) Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat.Rev.Drug Discov. 10 453 PMID: 21629295
If you know of a relevant reference for ML 171, please let us know.
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Keywords: ML 171, supplier, ML171, NADPH, oxidases, 1, NOX1, reactive, oxygen, species, ROS, inhibits, inhibitors, selective, cell, permeable, NADPH, Oxidase, NADPH, Oxidase, Tocris Bioscience
1 Citation for ML 171
Citations are publications that use Tocris products. Selected citations for ML 171 include:
Cheung et al (2016) Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Anal Bioanal Chem 30 52 PMID: 26679840
Do you know of a great paper that uses ML 171 from Tocris? If so please let us know.
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