Pricing Availability Delivery Time Qty
Cat.No. 5547 - MK6-83 | C16H20N2O2S2 | CAS No. 1062271-24-2
Description: TRPML channel activator
Chemical Name: 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
Purity: ≥98% (HPLC)

Biological Activity

TRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

Technical Data

M. Wt 336.47
Formula C16H20N2O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1062271-24-2
PubChem ID 18191179
Smiles CC3=CC=C(S3)S(NC1=CC=CC=C1N2CCCCC2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.65 100
ethanol 6.73 20

Preparing Stock Solutions

The following data is based on the product molecular weight 336.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.86 mL 29.72 mL
5 mM 0.59 mL 2.97 mL 5.94 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Chen et al (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 5 4681 PMID: 25119295

If you know of a relevant reference for MK6-83, please let us know.

View Related Products by Target

View Related Products by Product Action

View all TRPML Activators

Keywords: MK6-83, supplier, TRPML, transient, receptor, potential, channels, activators, activates, mucolipidosis, MLIV, TRPML, TRPML, Tocris Bioscience

Citations for MK6-83

Citations are publications that use Tocris products.

Currently there are no citations for MK6-83. Do you know of a great paper that uses MK6-83 from Tocris? If so please let us know.

MK6-83 Reviews

Average Rating:

(Based on 0 Reviews)

1 Star
2 Star
3 Star
4 Star
5 Star

Have you used MK6-83?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Literature in this Area


Autophagy Scientific Review

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.


Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.