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Biological Activity for MK6-83
MK6-83 is a TRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.
Technical Data for MK6-83
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MK6-83
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MK6-83
The following data is based on the product molecular weight 336.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.97 mL||14.86 mL||29.72 mL|
|5 mM||0.59 mL||2.97 mL||5.94 mL|
|10 mM||0.3 mL||1.49 mL||2.97 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
References for MK6-83
References are publications that support the biological activity of the product.
Chen et al (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 5 4681 PMID: 25119295
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Keywords: MK6-83, MK6-83 supplier, TRPML, transient, receptor, potential, channels, activators, activates, mucolipidosis, MLIV, 5547, Tocris Bioscience
2 Citations for MK6-83
Citations are publications that use Tocris products. Selected citations for MK6-83 include:
Giancarlo et al (2023) RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Nat Commun 14 2775 PMID: 37188688
Steven J et al (2018) Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation. FASEB J 32 782-794 PMID: 29030399
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Literature in this Area
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