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Description: TRPML channel activator
Chemical Name: 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)

Biological Activity for MK6-83

MK6-83 is a TRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

Technical Data for MK6-83

M. Wt 336.47
Formula C16H20N2O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1062271-24-2
PubChem ID 18191179
Smiles CC3=CC=C(S3)S(NC1=CC=CC=C1N2CCCCC2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MK6-83

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.65 100
ethanol 3.36 10

Preparing Stock Solutions for MK6-83

The following data is based on the product molecular weight 336.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.86 mL 29.72 mL
5 mM 0.59 mL 2.97 mL 5.94 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets for MK6-83

Certificate of Analysis / Product Datasheet
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References for MK6-83

References are publications that support the biological activity of the product.

Chen et al (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 5 4681 PMID: 25119295

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Keywords: MK6-83, MK6-83 supplier, TRPML, transient, receptor, potential, channels, activators, activates, mucolipidosis, MLIV, 5547, Tocris Bioscience

2 Citations for MK6-83

Citations are publications that use Tocris products. Selected citations for MK6-83 include:

Steven J et al (2018) Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation. FASEB J 32 782-794 PMID: 29030399

Giancarlo et al (2023) RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Nat Commun 14 2775 PMID: 37188688

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Autophagy Scientific Review

Autophagy Scientific Review

Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.

Autophagy Poster

Autophagy Poster

Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.