MK6-83

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Cat.No. 5547 - MK6-83 | C16H20N2O2S2 | CAS No. 1062271-24-2
Description: TRPML channel activator
Chemical Name: 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

TRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

Technical Data

M. Wt 336.47
Formula C16H20N2O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1062271-24-2
PubChem ID 18191179
InChI Key IRGYSXZCDAWOOC-UHFFFAOYSA-N
Smiles CC3=CC=C(S3)S(NC1=CC=CC=C1N2CCCCC2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.65 100
ethanol 6.73 20

Preparing Stock Solutions

The following data is based on the product molecular weight 336.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.86 mL 29.72 mL
5 mM 0.59 mL 2.97 mL 5.94 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 5 4681 PMID: 25119295


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Keywords: MK6-83, supplier, TRPML, transient, receptor, potential, channels, activators, activates, mucolipidosis, MLIV, TRPML, TRPML, Tocris Bioscience

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