MK 212 hydrochloride

Pricing Availability   Qty
Description: 5-HT2C agonist
Chemical Name: 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride
Purity: ≥99% (HPLC)
Citations (6)
Literature (3)

Biological Activity for MK 212 hydrochloride

MK 212 hydrochloride is a 5-HT receptor agonist; displays selectivity for 5-HT2C over 5-HT2A (IC50 values are 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively).

Technical Data for MK 212 hydrochloride

M. Wt 235.12
Formula C8H11ClN4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 61655-58-1
PubChem ID 198421
Smiles ClC1=CN=CC(N2CCNCC2)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MK 212 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 11.76 50 with gentle warming

Preparing Stock Solutions for MK 212 hydrochloride

The following data is based on the product molecular weight 235.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.51 mL 42.53 mL 85.06 mL
2.5 mM 1.7 mL 8.51 mL 17.01 mL
5 mM 0.85 mL 4.25 mL 8.51 mL
25 mM 0.17 mL 0.85 mL 1.7 mL

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Product Datasheets for MK 212 hydrochloride

Certificate of Analysis / Product Datasheet
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References for MK 212 hydrochloride

References are publications that support the biological activity of the product.

Conn and Sanders-Bush (1987) Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT2 and 5-HT1C) receptors. J.Pharmacol.Exp.Ther. 242 552 PMID: 3039120

Hemrick-Luecke and Fuller (1996) Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentration by quipazine and MK-212. Eur.J.Pharmacol. 311 207 PMID: 8891601

Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 56 1211 PMID: 23301527

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6 Citations for MK 212 hydrochloride

Citations are publications that use Tocris products. Selected citations for MK 212 hydrochloride include:

Bigford et al (2012) 5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-MthD.-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization. J Biol Chem 287 11049 PMID: 22291020

Yu and Yamaguchi (2010) Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis. J Biomed Sci 103 648 PMID: 19955293

Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728

Do you know of a great paper that uses MK 212 hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.