You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for MK 0677
MK 0677 is a high affinity ghrelin receptor agonist (pKi = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC50 = 1.3 nM) and enhances GH plasma levels in vivo. Also attenuates isoproterenol-induced lipolysis in rat adipocytes in vitro. Orally bioavailable.
Compound Libraries for MK 0677
Technical Data for MK 0677
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MK 0677
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MK 0677
The following data is based on the product molecular weight 624.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.6 mL||8 mL||16.01 mL|
|5 mM||0.32 mL||1.6 mL||3.2 mL|
|10 mM||0.16 mL||0.8 mL||1.6 mL|
|50 mM||0.03 mL||0.16 mL||0.32 mL|
References for MK 0677
References are publications that support the biological activity of the product.
Bennett et al (2009) GH secretagogues and GH releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor. Mol.Pharmacol. 76 802 PMID: 19625579
Patchett et al (1995) Design and biological activities of L-163,191 (MK-0677): a potent, orally active GH secretagogue. Proc.Natl.Acad.Sci.U.S.A. 92 7001 PMID: 7624358
Mucciolo et al (2004) Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a GH secretagogue receptor. Eur.J.Pharmacol. 498 27 PMID: 15363972
If you know of a relevant reference for MK 0677, please let us know.
View Related Products by Product Action
Keywords: MK 0677, MK 0677 supplier, MK0677, high, affinity, ghrelin, receptors, agonists, growth, hormone, GH, secretagogue, orally, bioavailable, L-163,191, Ibutamoren, mesylate, Ghrelin, Receptors, 5272, Tocris Bioscience
1 Citation for MK 0677
Citations are publications that use Tocris products. Selected citations for MK 0677 include:
Pastor-Cavada et al (2016) A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity In vivo Scientific Reports 6 36456 PMID: 27819353
Do you know of a great paper that uses MK 0677 from Tocris? Please let us know.
Reviews for MK 0677
There are currently no reviews for this product. Be the first to review MK 0677 and earn rewards!
Have you used MK 0677?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.