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High affinity ghrelin receptor agonist (pKi = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC50 = 1.3 nM) and enhances GH plasma levels in vivo. Also attenuates isoproterenol-induced lipolysis in rat adipocytes in vitro. Orally bioavailable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 624.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.6 mL||8 mL||16.01 mL|
|5 mM||0.32 mL||1.6 mL||3.2 mL|
|10 mM||0.16 mL||0.8 mL||1.6 mL|
|50 mM||0.03 mL||0.16 mL||0.32 mL|
References are publications that support the biological activity of the product.
Bennett et al (2009) GH secretagogues and GH releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor. Mol.Pharmacol. 76 802 PMID: 19625579
Patchett et al (1995) Design and biological activities of L-163,191 (MK-0677): a potent, orally active GH secretagogue. Proc.Natl.Acad.Sci.U.S.A. 92 7001 PMID: 7624358
Mucciolo et al (2004) Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a GH secretagogue receptor. Eur.J.Pharmacol. 498 27 PMID: 15363972
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Keywords: MK 0677, MK 0677 supplier, MK0677, high, affinity, ghrelin, receptors, agonists, growth, hormone, GH, secretagogue, orally, bioavailable, L-163,191, Ibutamoren, mesylate, Ghrelin, Receptors, 5272, Tocris Bioscience
1 Citation for MK 0677
Citations are publications that use Tocris products. Selected citations for MK 0677 include:
Pastor-Cavada et al (2016) A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity In vivo Scientific Reports 6 36456 PMID: 27819353
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.