(-)-JQ1

Pricing Availability   Qty

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Description: Negative control for (+)-JQ1
Chemical Name: (6R)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (6)

Biological Activity for (-)-JQ1

(-)-JQ1 is an inactive control for (+)-JQ1. Exhibits no significant interaction with BRD1-4 or a panel of other bromodomains.

Active Enantiomer also available.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (+)-JQ1 probe summary on the SGC website.

Compound Libraries for (-)-JQ1

(-)-JQ1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for (-)-JQ1

M. Wt 456.99
Formula C23H25ClN4O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1268524-71-5
PubChem ID 49871818
InChI Key DNVXATUJJDPFDM-QGZVFWFLSA-N
Smiles O=C(OC(C)(C)C)C[C@H]1N=C(C4=CC=C(Cl)C=C4)C3=C(SC(C)=C3C)N2C1=NN=C2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (-)-JQ1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.7 100
ethanol 45.7 100

Preparing Stock Solutions for (-)-JQ1

The following data is based on the product molecular weight 456.99. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.94 mL 21.88 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.09 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for (-)-JQ1

References are publications that support the biological activity of the product.

Filippakopoulos et al (2010) Selective inhibition of BET bromodomains. Nature 468 1067 PMID: 20871596


If you know of a relevant reference for (-)-JQ1, please let us know.

View Related Products by Target

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View all Bromodomain Controls

Keywords: (-)-JQ1, (-)-JQ1 supplier, inactive, analogs, negative, controls, bromodomains, BRD1, BRD2, BRD3, BRD4, Bromodomains, 5603, Tocris Bioscience

2 Citations for (-)-JQ1

Citations are publications that use Tocris products. Selected citations for (-)-JQ1 include:

Perry et al (2015) BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle. Scientific Reports 290 9111 PMID: 25697361

Andrieu et al (2019) BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response. Cancer Lett 465 45 PMID: 31473251


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Reviews for (-)-JQ1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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