(-)-Indolactam V

Discontinued Product

Unfortunately (-)-Indolactam V (Cat. No. 3651) has been withdrawn from sale for commercial reasons.
Cat.No. 3651 - (-)-Indolactam V | C17H23N3O2 | CAS No. 90365-57-4
Description: Protein kinase C activator
Chemical Name: (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
Purity: ≥99% (HPLC)

Biological Activity

Protein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.

Technical Data

M. Wt 301.38
Formula C17H23N3O2
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 90365-57-4
Smiles O=C(N[C@@H](C3)CO)[C@H]([C@H](C)C)N(C)C1=CC=CC2=C1C3=CN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 301.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.32 mL 16.59 mL 33.18 mL
5 mM 0.66 mL 3.32 mL 6.64 mL
10 mM 0.33 mL 1.66 mL 3.32 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet


References are publications that support the products' biological activity.

Geiges et al (1997) Activation of protein kinase C subtypes α, γ, δ, ε, ζ and η by tumor-promoting and nontumor-promoting agents. Biochem.Pharmacol. 53 865 PMID: 9113106

Masuda et al (2002) Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes. Biosci.Biotechnol.Biochem. 66 1615 PMID: 12224655

Chen et al (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 5 258 PMID: 19287398

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