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Discontinued Product(-)-Indolactam V (Cat. No. 3651) has been withdrawn from sale for commercial reasons.
Protein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Geiges et al (1997) Activation of protein kinase C subtypes α, γ, δ, ε, ζ and η by tumor-promoting and nontumor-promoting agents. Biochem.Pharmacol. 53 865 PMID: 9113106
Masuda et al (2002) Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes. Biosci.Biotechnol.Biochem. 66 1615 PMID: 12224655
Chen et al (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 5 258 PMID: 19287398
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Keywords: (-)-Indolactam V, (-)-Indolactam V supplier, Protein, kinases, C, activators, PKC, (-)-IndolactamV, Kinase, Enzyme, Substrates, /, Activators, 3651, Tocris Bioscience
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