(-)-Indolactam V

Discontinued Product

(-)-Indolactam V (Cat. No. 3651) has been withdrawn from sale for commercial reasons.
Description: Protein kinase C activator
Chemical Name: (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
Purity: ≥99% (HPLC)

Biological Activity for (-)-Indolactam V

Protein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.

Technical Data for (-)-Indolactam V

M. Wt 301.38
Formula C17H23N3O2
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 90365-57-4
Smiles O=C(N[C@@H](C3)CO)[C@H]([C@H](C)C)N(C)C1=CC=CC2=C1C3=CN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for (-)-Indolactam V

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for (-)-Indolactam V

References are publications that support the biological activity of the product.

Geiges et al (1997) Activation of protein kinase C subtypes α, γ, δ, ε, ζ and η by tumor-promoting and nontumor-promoting agents. Biochem.Pharmacol. 53 865 PMID: 9113106

Masuda et al (2002) Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes. Biosci.Biotechnol.Biochem. 66 1615 PMID: 12224655

Chen et al (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 5 258 PMID: 19287398

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Keywords: (-)-Indolactam V, (-)-Indolactam V supplier, Protein, kinases, C, activators, PKC, (-)-IndolactamV, Kinase, Enzyme, Substrates, /, Activators, 3651, Tocris Bioscience

Citations for (-)-Indolactam V

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