Discontinued ProductUnfortunately (-)-Indolactam V (Cat. No. 3651) has been withdrawn from sale for commercial reasons.
Protein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 301.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.32 mL||16.59 mL||33.18 mL|
|5 mM||0.66 mL||3.32 mL||6.64 mL|
|10 mM||0.33 mL||1.66 mL||3.32 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
References are publications that support the products' biological activity.
Geiges et al (1997) Activation of protein kinase C subtypes α, γ, δ, ε, ζ and η by tumor-promoting and nontumor-promoting agents. Biochem.Pharmacol. 53 865 PMID: 9113106
Masuda et al (2002) Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes. Biosci.Biotechnol.Biochem. 66 1615 PMID: 12224655
Chen et al (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 5 258 PMID: 19287398
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Keywords: (-)-Indolactam V, supplier, Protein, kinases, C, activators, PKC, (-)-IndolactamV, Protein, Kinase, C, Enzyme, Substrates, /, Activators, Protein, Kinase, C, Tocris Bioscience
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